Induction of adrenomedullin 2/intermedin expression by thyroid stimulating hormone in thyroid

被引：10

作者：

Nagasaki, Shuji ^{[1
,2
]}

Fukui, Motoko ^{[3
]}

Asano, Satoko ^{[1
]}

Ono, Katsuhiko ^{[2
]}

Miki, Yasuhiro ^{[2
]}

Araki, Sei-ichi ^{[3
]}

Isobe, Mitsui ^{[3
]}

Nakashima, Noriaki ^{[4
]}

Takahashi, Kazuhiro ^{[5
]}

Sasano, Hironobu ^{[2
]}

Sato, Jun ^{[1
]}

机构：

[1] ASKA Pharmaceut Co Ltd, Drug Discovery Dept, Kawasaki, Kanagawa 2138522, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Pathol, Sendai, Miyagi 980, Japan

[3] ASKA Pharmaceut Co Ltd, Safety Res Dept, Kawasaki, Kanagawa 2138522, Japan

[4] Tohoku Univ Hosp, Dept Breast & Endocrine Surg, Sendai, Miyagi, Japan

[5] Tohoku Univ, Grad Sch Med, Dept Endocrinol & Appl Med Sci, Sendai, Miyagi 980, Japan

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2014年 / 395卷 / 1-2期

关键词：

Goiter; Iodine-deficiency; Adrenomedullin; 2; Intermedin; Immunohistochemistry; ENDOTHELIAL GROWTH-FACTOR; GENE-RELATED PEPTIDE; OXIDE SYNTHASE III; IODINE DEFICIENCY; NITRIC-OXIDE; THYROTROPIN RECEPTOR; THYROGLOBULIN GENE; IN-VITRO; RAT; CELLS;

D O I：

10.1016/j.mce.2014.07.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TSH is the important regulator of thyroid function but detailed molecular mechanisms have not been clarified. We first generated the iodine deficient (ID) rat in which goiter is induced by accelerated endogenous TSH secretion. The result of microarray analysis demonstrated markedly increased levels of adrenomedullin 2/intermedin (AM2/IMD) expression in the ID rat thyroid. AM2/IMD is a potent vasodilator. AM2/IMD mRNA expression was induced by TSH in a rat thyroid follicular cell line FRTL-5. Immunohistochemical analysis in human normal and Graves' disease thyroid revealed that AM2/IMD immunoreactivity was detected in follicular cells and more pronounced in Graves' disease. These results indicated that TSH induced AM2/IMD expression in the rat thyroid gland and it could locally work as a potent vasodilator, resulting in the expansion of thyroid inter-follicular capillaries. AM2/IMD could also contribute to facilitate thyroid hormone synthesis possibly via vasodilation effects and/or cAMP stimulating effects in the human thyroid gland. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：32 / 40

页数：9

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