Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism

被引：10
作者：
Espinosa-Salinas, Isabel [1 ]
Colmenarejo, Gonzalo [1 ]
Fernandez-Diaz, Cristina M. [1 ]
Gomez de Cedron, Marta [1 ]
Alfredo Martinez, J. [1 ,2 ,3 ]
Reglero, Guillermo [1 ,4 ]
Ramirez de Molina, Ana [1 ]
机构：
[1] CEI UAM CSIC, IMDEA Food Inst, Madrid 28049, Spain
[2] Navarra Inst Hlth Res IdiSNA, Ctr Nutr Res CIN, Pamplona 31008, Spain
[3] Inst Hlth Carlos III, Ctr Biomed Res Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain
[4] CEI UAM CSIC, Inst Food Sci Res CIAL, Madrid 28049, Spain
来源：
SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期
关键词：
GENOME-WIDE ASSOCIATION; CLOCK GENE; CIRCADIAN CLOCK; APOLIPOPROTEIN; DISEASE; LIPOPROTEIN; RISK; METAANALYSIS; CHOLESTEROL; REDUCTION;
D O I：
10.1038/s41598-022-10923-4
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public health emergency. Increasing understanding about predisposing factors to infection and severity is now a priority. Genetic, metabolic, and environmental factors can play a crucial role in the course and clinical outcome of COVID-19. We aimed to investigate the putative relationship between genetic factors associated to obesity, metabolism and lifestyle, and the presence and severity of SARS-CoV-2 infection. A total of 249 volunteers (178 women and 71 men, with mean and +/- SD age of 49 +/- 11 years) characterized for dietary, lifestyle habits and anthropometry, were studied for presence and severity of COVID-19 infection, and genotyped for 26 genetic variants related to obesity, lipid profile, inflammation, and biorhythm patterns. A statistically significant association was found concerning a protective effect of APOE rs7412 against SARS-CoV-2 infection (p = 0.039; OR 0.216; CI 0.084, 0.557) after correction for multiple comparisons. This protective effect was also ascribed to the APOe2 allele (p = 0.001; OR 0.207; CI 0.0796, 0.538). The genetic variant rs7412 resulting in ApoE2, genetic determinant of lipid and lipoprotein levels, could play a significant role protecting against SARS-CoV-2 infection.
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页数：11
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