Molecular mechanisms that confer antibacterial drug resistance

被引：1187

作者：

Walsh, C ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

NATURE | 2000年 / 406卷 / 6797期

关键词：

D O I：

10.1038/35021219

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antibiotics - compounds that are literally 'against life' - are typically antibacterial drugs, interfering with some structure or process that is essential to bacterial growth or survival without harm to the eukaryotic host harbouring the infecting bacteria. We live in an era when antibiotic resistance has spread at an alarming rate(1-4) and when dire predictions concerning the lack of effective antibacterial drugs occur with increasing frequency. In this context it is apposite to ask a few simple questions about these life-saving molecules. What are antibiotics? Where do they come from? How do they work? Why do they stop being effective? How do we find new antibiotics? And can we slow down the development of antibiotic-resistant superbugs?

引用

页码：775 / 781

页数：7

共 64 条

[1]

AGOURIDAS C, 1995, 35 INT C ANT AG CHEM, pF158

[2]

[Anonymous], 1985, HDB EXPT PHARM

[3] GENETICS AND MECHANISMS OF GLYCOPEPTIDE RESISTANCE IN ENTEROCOCCI [J].

ARTHUR, M ;

COURVALIN, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) :1563-1571

[4]

Barrett J. F., 1995, ANNU REP MED CHEM, V30, P111, DOI 10.1016/s0065-7743(08)60925-2

[5] Two-component signal transduction as a target for microbial anti-infective therapy [J].

Barrett, JF ;

Hoch, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (07) :1529-1536

[6] IN-VITRO ACTIVITIES OF A STREPTOGRAMIN (RP59500), 3 MACROLIDES, AND AN AZALIDE AGAINST 4 RESPIRATORY-TRACT PATHOGENS [J].

BARRY, AL ;

FUCHS, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (01) :238-240

[7] In vitro antibacterial activity of LY333328, a new semisynthetic glycopeptide [J].

Biavasco, F ;

Vignaroli, C ;

Lupidi, R ;

Manso, E ;

Facinelli, B ;

Varaldo, PE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (10) :2165-2172

[8] MECHANISM OF ACTION OF SPIRAMYCIN AND OTHER MACROLIDES [J].

BRISSONNOEL, A ;

TRIEUCUOT, P ;

COURVALIN, P .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 22 :13-23

[9] MOLECULAR-BASIS FOR VANCOMYCIN RESISTANCE IN ENTEROCOCCUS-FAECIUM BM4147 - BIOSYNTHESIS OF A DEPSIPEPTIDE PEPTIDOGLYCAN PRECURSOR BY VANCOMYCIN RESISTANCE PROTEINS VANH AND VANA [J].

BUGG, TDH ;

WRIGHT, GD ;

DUTKAMALEN, S ;

ARTHUR, M ;

COURVALIN, P ;

WALSH, CT .

BIOCHEMISTRY, 1991, 30 (43) :10408-10415

[10] Crystal structure of ErmC′, an rRNA methyltransferase which mediates antibiotic resistance in bacteria [J].

Bussiere, DE ;

Muchmore, SW ;

Dealwis, CG ;

Schluckebier, G ;

Nienaber, VL ;

Edalji, RP ;

Walter, KA ;

Ladror, US ;

Holzman, TF ;

Abad-Zapatero, C .

BIOCHEMISTRY, 1998, 37 (20) :7103-7112

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