Function and Role of Regulatory T Cells in Rheumatoid Arthritis

被引：168

作者：

Jiang, Qi ^{[1
]}

Yang, Guocan ^{[1
]}

Liu, Qi ^{[1
]}

Wang, Shengjun ^{[2
,3
]}

Cui, Dawei ^{[4
]}

机构：

[1] Zhejiang Univ, Sch Med, Shaoxing Peoples Hosp, Dept Blood Transfus,Shaoxing Hosp, Shaoxing, Peoples R China

[2] Jiangsu Univ, Affiliated Peoples Hosp, Dept Lab Med, Zhenjiang, Jiangsu, Peoples R China

[3] Jiangsu Univ, Sch Med, Dept Immunol, Jiangsu Key Lab,Lab Med, Zhenjiang, Jiangsu, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Blood Transfus, Hangzhou, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

Treg cells; rheumatoid arthritis; autoimmune diseases; immune tolerance; transcription factor Foxp3; PERIPHERAL-BLOOD; DENDRITIC CELLS; TREG; HOMEOSTASIS; EXPRESSION; CD4(+);

D O I：

10.3389/fimmu.2021.626193

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rheumatoid arthritis (RA) is a systemic and heterogeneous autoimmune disease with symmetrical polyarthritis as its critical clinical manifestation. The basic cause of autoimmune diseases is the loss of tolerance to self or harmless antigens. The loss or functional deficiency of key immune cells, regulatory T (Treg) cells, has been confirmed in human autoimmune diseases. The pathogenesis of RA is complex, and the dysfunction of Tregs is one of the proposed mechanisms underlying the breakdown of self-tolerance leading to the progression of RA. Treg cells are a vital component of peripheral immune tolerance, and the transcription factor Foxp3 plays a major immunosuppressive role. Clinical treatment for RA mainly utilizes drugs to alleviate the progression of disease and relieve disease activity, and the ideal treatment strategy should be to re-induce self-tolerance before obvious tissue injury. Treg cells are one of the ideal options. This review will introduce the classification, mechanism of action, and characteristics of Treg cells in RA, which provides insights into clinical RA treatment.

引用

页数：12

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