Phenolic Components from the Leaves of Panax ginseng and Their Effects on HL-60 Human Leukemia Cells

被引：12

作者：

Tung, Nguyen Hun ^{[1
]}

Son, Jeong-Hyun ^{[1
]}

Cho, Kyoungwon ^{[1
]}

Kim, Jeong-Ah ^{[1
]}

Hyun, Jae-Hee ^{[2
]}

Kang, Hee-Kyoung ^{[2
]}

Song, Gyu Yong ^{[1
]}

Park, Chun Jung ^{[3
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Jeju Natl Univ, Inst Med Sci, Sch Med, Cheju 690756, South Korea

[3] Geumsan Ginseng Cooperat Assoc, Geumsan 312800, Chungnam, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2010年 / 19卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Panax ginseng; Araliaceae; flavonoid; cytotoxic activity; HL-60; cell; apoptosis;

D O I：

10.1007/s10068-010-0040-z

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study investigates phenolic components from the Panax ginseng C.A. Meyer leaves led to, the isolation of 3 flavonoids (1-3). Their structures were characterized on the basis of physicochemical properties, nuclear magnetic resonance (NMR) spectra, electron spray ionization-mass spectrometry (ESI-MS) data, and comparison with those in the literature. Of them, sophoraflavonoloside (2) and prunin (3) were found to inhibit the growth of HL-60 human leukemia cells with IC50 in values of 29.8 and 21.4 mu M by the induction of apoptosis.

引用

页码：271 / 274

页数：4

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