Subchondral bone microenvironment in osteoarthritis and pain

被引:266
|
作者
Hu, Yan [1 ]
Chen, Xiao [1 ]
Wang, Sicheng [2 ,3 ]
Jing, Yingying [2 ]
Su, Jiacan [1 ]
机构
[1] Naval Mil Med Univ, Shanghai Changhai Hosp, Dept Orthoped Trauma, Shanghai, Peoples R China
[2] Shanghai Univ, Inst Translat Med, Shanghai, Peoples R China
[3] Shanghai Zhongye Hosp, Dept Orthoped, Shanghai, Peoples R China
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
D O I
10.1038/s41413-021-00147-z
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Osteoarthritis comprises several joint disorders characterized by articular cartilage degeneration and persistent pain, causing disability and economic burden. The incidence of osteoarthritis is rapidly increasing worldwide due to aging and obesity trends. Basic and clinical research on osteoarthritis has been carried out for decades, but many questions remain unanswered. The exact role of subchondral bone during the initiation and progression osteoarthritis remains unclear. Accumulating evidence shows that subchondral bone lesions, including bone marrow edema and angiogenesis, develop earlier than cartilage degeneration. Clinical interventions targeting subchondral bone have shown therapeutic potential, while others targeting cartilage have yielded disappointing results. Abnormal subchondral bone remodeling, angiogenesis and sensory nerve innervation contribute directly or indirectly to cartilage destruction and pain. This review is about bone-cartilage crosstalk, the subchondral microenvironment and the critical role of both in osteoarthritis progression. It also provides an update on the pathogenesis of and interventions for osteoarthritis and future research targeting subchondral bone.
引用
收藏
页数:13
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