Natural and non-natural antioxidative compounds: potential candidates for treatment of vascular calcification

被引：52

作者：

Chao, Chia-Ter ^{[1
,2
,3
]}

Yeh, Hsiang-Yuan ^{[4
]}

Tsai, You-Tien ^{[3
]}

Chuang, Pei-Huan ^{[3
]}

Yuan, Tzu-Hang ^{[3
]}

Huang, Jenq-Wen ^{[5
]}

Chen, Huei-Wen ^{[3
]}

机构：

[1] Natl Taiwan Univ, Dept Med, Natl Taiwan Univ Hosp, BeiHu Branch,Coll Med, Taipei, Taiwan

[2] Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei, Taiwan

[3] Natl Taiwan Univ, Grad Inst Toxicol, Coll Med, Taipei, Taiwan

[4] Soochow Univ, Sch Big Data Management, Taipei, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Internal Med, Nephrol Div, Taipei, Taiwan

来源：

CELL DEATH DISCOVERY | 2019年 / 5卷 / 1期

关键词：

SMOOTH-MUSCLE-CELLS; OXIDATIVE-STRESS; SODIUM THIOSULFATE; ARTERIAL CALCIFICATION; IN-VITRO; MEDIAL CALCIFICATION; DISEASE; ACID; BONE; ACTIVATION;

D O I：

10.1038/s41420-019-0225-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vascular calcification (VC) is highly prevalent in patients with advanced age, or those with chronic kidney disease and diabetes, accounting for substantial global cardiovascular burden. The pathophysiology of VC involves active mineral deposition by transdifferentiated vascular smooth muscle cells exhibiting osteoblast-like behavior, building upon cores with or without apoptotic bodies. Oxidative stress drives the progression of the cellular phenotypic switch and calcium deposition in the vascular wall. In this review, we discuss potential compounds that shield these cells from the detrimental influences of reactive oxygen species as promising treatment options for VC. A comprehensive summary of the current literature regarding antioxidants for VC is important, as no effective therapy is currently available for this disease. We systematically searched through the existing literature to identify original articles investigating traditional antioxidants and novel compounds with antioxidant properties with regard to their effectiveness against VC in experimental or clinical settings. We uncovered 36 compounds with antioxidant properties against VC pathology, involving mechanisms such as suppression of NADPH oxidase, BMP-2, and Wnt/beta-catenin; anti-inflammation; and activation of Nrf2 pathways. Only two compounds have been tested clinically. These findings suggest that a considerable opportunity exists to harness these antioxidants for therapeutic use for VC. In order to achieve this goal, more translational studies are needed.

引用

页数：11

共 88 条

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