Childhood Chronic Myeloid Leukemia with Monocytosis

被引：3

作者：

Gupta, Nidhi ^{[1
]}

Gupta, Ritu ^{[1
]}

Sharawat, Surender Kumar ^{[2
]}

Bakhshi, Sameer ^{[2
]}

机构：

[1] All India Inst Med Sci, Lab Oncol Unit, Dr BR Ambedkar Inst, Rotary Canc Hosp, New Delhi 110029, India

[2] All India Inst Med Sci, Dept Med Oncol, Dr BR Ambedkar Inst, Rotary Canc Hosp, New Delhi 110029, India

来源：

INDIAN JOURNAL OF PEDIATRICS | 2010年 / 77卷 / 10期

关键词：

CML; Monocytosis; Major BCR breakpoint; CHRONIC MYELOGENOUS LEUKEMIA; P190(BCR-ABL);

D O I：

10.1007/s12098-010-0200-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report two cases of chronic myeloid leukemia (CML) in childhood presenting with monocytosis. History, physical examination and laboratory findings were in favor of juvenile myelomonocytic leukemia in both the cases, but reverse transcriptase polymerase chain reaction (RT-PCR) detected b2a2 and b3a2 transcript of p210 bcr-abl protein characteristic of major BCR breakpoint. Presence of monocytosis in early childhood suggests a viral infection or JMML but a possibility of CML with monocytosis needs to be considered.

引用

页码：1143 / 1145

页数：3

共 9 条

[1] Lymphoid preponderance and the absence of basophilia and splenomegaly are frequent in m-bcr-positive chronic myelogenous leukemia [J].