LC-MS/MS Bioanalytical Method for Simultaneous Quantification of Three H1-Antihistaminic Drugs in Human Plasma

被引：0
作者：
Caba, Ioana Cezara [1 ]
Cioroiu, Bogdan Ionel [2 ]
Butnaru, Elena [1 ]
Jitareanu, Alexandra [1 ]
Agoroaei, Luminita [1 ]
机构：
[1] Grigore T Popa Univ Med & Pharm, Fac Pharm, 16th Univ Str, Iasi 700115, Romania
[2] Grigore T Popa Univ Med & Pharm, ChemPerformance Lab, 16th Univ Str, Iasi 700115, Romania
来源：
REVISTA DE CHIMIE | 2019年 / 70卷 / 11期
关键词：
H-1-antihistaminic drugs; human plasma; LC-MS/MS; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; ACTIVE METABOLITE; LORATADINE; DESLORATADINE; PSEUDOEPHEDRINE; CETIRIZINE; 3-HYDROXYDESLORATADINE; PHARMACOKINETICS; QUANTITATION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of the study was to validate a bioanalytical method, for quantifying desloratadine, loratadine and cetirizine in biological samples, useful in toxicological studies. The analytical performance was investigated using the following parameters: selectivity, limit of detection and quantification, linearity, precision, accuracy, matrix effect and analytical stability in the biological matrix. The method optimization was performed for the LC-MS/MS Ultimate 3000 instrument provided by Thermo Fisher Scientific.
引用
收藏
页码：4047 / 4052
页数：6
相关论文
共 23 条
[1]   Optimization by factorial design of a capillary zone electrophoresis method for the simultaneous separation of antihistamines [J].
Capella-Peiro, ME ;
Bossi, A ;
Esteve-Romero, J .
ANALYTICAL BIOCHEMISTRY, 2006, 352 (01) :41-49
[2]  
El-Kommos M. E., 2015, ANAL CHEM RES, V3, P1, DOI [10.1016/j.ancr.2014.11.003, DOI 10.1016/J.ANCR.2014.11.003]
[3]   Simultaneous screening and quantitation of 18 antihistamine drugs in blood by liquid chromatography ionspray tandem mass spectrometry [J].
Gergov, M ;
Robson, JN ;
Ojanperä, I ;
Heinonen, OP ;
Vuori, E .
FORENSIC SCIENCE INTERNATIONAL, 2001, 121 (1-2) :108-115
[4]   Simultaneous Determination of Loratadine, Desloratadine and Cetirizine by Capillary Zone Electrophoresis [J].
Hancu, Gabriel ;
Campian, Camelia ;
Rusu, Aura ;
Mircia, Eleonora ;
Kelemen, Hajnal .
ADVANCED PHARMACEUTICAL BULLETIN, 2014, 4 (02) :161-165
[5]   Simultaneous determination of desloratadine and montelukast sodium using second-derivative synchronous fluorescence spectrometry enhanced by an organized medium with applications to tablets and human plasma [J].
Ibrahim, F. A. ;
El-Enany, N. ;
El-Shaheny, R. N. ;
Mikhail, I. E. .
LUMINESCENCE, 2015, 30 (04) :485-494
[6]  
KUMAR V. P., 2013, INT J PHARM PHARM SC, V5, P684
[7]   Development and evaluation of an efficient HPLC/MS/MS method for the simultaneous determination of pseudoephedrine and cetirizine in human plasma: Application to phase-I pharmacokinetic study [J].
Ma Ming ;
Feng Fang ;
Sheng Yulan ;
Cui Shuangjin ;
Liu Han .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 846 (1-2) :105-111
[8]   LC-MS-ESI for the Determination of Loratadine and Descarboethoxyloratadine in Human Plasma [J].
Patel, Bhavin N. ;
Sharma, Naveen ;
Sanyal, Mallika ;
Shrivastav, Pranav S. .
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2010, 48 (01) :35-44
[9]   Simultaneous determination of montelukast and loratadine by HPLC and derivative spectrophotometric methods [J].
Radhakrishna, T ;
Narasaraju, A ;
Ramakrishna, M ;
Satyanarayana, A .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2003, 31 (02) :359-368
[10]   Capillary electrophoresis determination of antihistamines in serum and pharmaceuticals [J].
Rambla-Alegre, Maria ;
Peris-Vicente, Juan ;
Esteve-Romero, Josep ;
Capella-Peiro, Maria-Elisa ;
Bose, Devasish .
ANALYTICA CHIMICA ACTA, 2010, 666 (1-2) :102-109
123