Common cholesteryl ester transfer protein gene variation related to high-density lipoprotein cholesterol is not associated with decreased coronary heart disease risk after a 10-year follow-up in a Mediterranean cohort: Modulation by alcohol consumption

被引：18

作者：

Corella, Dolores ^{[1
,2
]}

Carrasco, Paula ^{[1
,2
]}

Amiano, Pilar ^{[3
]}

Arriola, Larraitz ^{[3
]}

Dolores Chirlaque, Maria ^{[4
]}

Maria Huerta, Jose ^{[4
]}

Martinez, Carmen ^{[5
]}

Martinez-Camblor, Pablo ^{[3
]}

Molina, Esther ^{[5
]}

Navarro, Carmen ^{[4
]}

Quiros, Juan R. ^{[6
]}

Rodriguez, Laudina ^{[6
]}

Jose Sanchez, Maria ^{[5
]}

Ortega-Azorin, Carolina ^{[1
,2
]}

Ros, Emilio ^{[2
,7
]}

Sala, Nuria ^{[8
]}

Gonzalez, Carlos A. ^{[8
]}

Moreno, Concepcion ^{[9
]}

机构：

[1] Univ Valencia, Sch Med, Dept Prevent Med, Genet & Mol Epidemiol Unit, Valencia, Spain

[2] ISCIII, CIBER Fisiopatol Obesidad & Nutr, Valencia 46010, Spain

[3] Basque Govt, Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[4] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[5] Andalusian Sch Publ Hlth, Granada, Spain

[6] Direcc Gen Salud Publ & Planificac, Asturias, Spain

[7] Hosp Clin Barcelona, Barcelona, Spain

[8] ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[9] Publ Hlth Inst Navarra, Pamplona, Spain

来源：

ATHEROSCLEROSIS | 2010年 / 211卷 / 02期

关键词：

CETP; Polymorphism; Cardiovascular risk; Alcohol; TAQIB POLYMORPHISM; LIPID-LEVELS; MYOCARDIAL-INFARCTION; ARTERY-DISEASE; CETP GENE; HDL; VARIANTS; CANCER; LIFE;

D O I：

10.1016/j.atherosclerosis.2010.03.026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Despite the consistent association between cholesteryl ester transfer protein (CETP) gene variation and plasma HDL-C, huge controversy still rages on its association with coronary heart disease (CHD). We investigated the association between the CETP-TaqIB polymorphism, HDL-C and incident CHD in a Mediterranean population. Methods: A nested case-control study among participants of the Spanish EPIC cohort was performed. 41,440 healthy individuals (30-69 years) were followed up over a 10-year period, incident CHD cases being identified. We analyzed 557 confirmed CHD cases and 1180 healthy controls. Results: Despite B2B2 subjects having the highest HDL-C concentrations and B1B1, the lowest (P < 0.001), no protective effect of the B2 allele against CHD incidence was observed. Thus, in comparison with B1B1 subjects, the adjusted CHD risk of B1B2 was OR: 1.00, 95% CI: 0.80-1.26; P = 0.982, and that of B2B2 was OR: 1.16, 95% CI: 0.84-1.61; P = 0.374. These results did not change after adjustment for HDL-C. No significant interaction between alcohol consumption and the CETP-TaqIB polymorphism in determining HDL-C was found. However, a different effect of this polymorphism on CHD risk in drinkers and nondrinkers was observed. In non-drinkers, the B2B2 genotype was associated with a non-significant lower CHD risk, whereas in drinkers it was associated with a greater risk (OR: 1.55, 95% CI: 1.05-2.29; P = 0.026). We also observed that in diabetics (11% cases and 7.4% controls), the B2 allele was significantly associated with higher CHD risk. Conclusions: In this Mediterranean population, the CETP-TaqIB polymorphism was not associated with a lower CHD incidence, and its effect was modulated by alcohol and possibly by diabetes. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：531 / 538

页数：8

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