Recent developments of 2-aminothiazoles in medicinal chemistry

被引：176
作者：
Das, Debasis [1 ]
Sikdar, Papiya [1 ]
Bairagi, Moumita [1 ]
机构：
[1] Sree Chaitanya Coll, Post Grad Dept Chem, Habra 743268 24, Parganas, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 109卷
关键词：
2-Aminothiazole; Thiazole; Review; Bioactive; Drugs; Medicinal chemistry; Pharmacological activity; CYCLIN-DEPENDENT KINASE; IN-VITRO ACTIVITY; BIOLOGICAL EVALUATION; SCHIFF-BASES; DERIVATIVES; DISCOVERY; INHIBITORS; DESIGN; THIAZOLES; AGENTS;
D O I：
10.1016/j.ejmech.2015.12.022
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The 2-aminothiazole (2-AT) core is an active pharmacophore and used in medicinal chemistry and drug discovery research. A number of drugs with 2-AT core are in the market, e.g. Famotidine, Cefdinir, Meloxcam etc. Recently, 2-AT core has been explored for many more important therapeutic areas and identified new 2-aminothiazoles with anticancer, antitumor, antidiebatic and anticonvulsant activity. In this review, we discuss the newly identified and developed 2-aminothiazoles in recent years and their use in medicinal chemistry and pharmacology. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：89 / 98
页数：10
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  • [1] Synthesis and reactions of thiosemicarbazides, triazoles, and Schiff bases as antihypertensive α-blocking agents
    Abdel-Wahab, Bakr F.
    Mohamed, Salwa F.
    Amr, Abd El-Galil E.
    Abdalla, Mohamed M.
    [J]. MONATSHEFTE FUR CHEMIE, 2008, 139 (09): : 1083 - 1090
  • [2] Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1, 3-thiazol-2-yl]-1H-pyrazoles
    Abdel-Wahab, Bakr F.
    Abdel-Aziz, Hatem A.
    Ahmed, Essam M.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (06) : 2632 - 2635
  • [3] DNA binding of ethyl 2-substituted aminothiazole-4-carboxylate analogues: A molecular modeling approach to predict their antitumor activity
    Abouzeid, Laila A.
    El-Subbagh, Hussein, I
    [J]. FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 1 (01) : 1 - 7
  • [4] Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents
    Amin, Kamelia M.
    Rahman, Doaa E. Abdel
    Al-Eryani, Yasmin A.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (10) : 5377 - 5388
  • [5] Synthesis, spectral and biological evaluation of some new thiazolidinones and thiazoles based on t-3-alkyl-r-2,c-6-diarylpiperidin-4-ones
    Aridoss, G.
    Amirthaganesan, S.
    Kim, M. S.
    Kim, J. T.
    Jeong, Yeon Tae
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) : 4199 - 4210
  • [6] Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives
    Arshad, Afsheen
    Osman, Hasnah
    Bagley, Mark C.
    Lam, Chan Kit
    Mohamad, Suriyati
    Zahariluddin, Anis Safirah Mohd
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (09) : 3788 - 3794
  • [7] Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery
    Ayati, Adile
    Emami, Saeed
    Asadipour, Ali
    Shafiee, Abbas
    Foroumadi, Alireza
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 97 : 699 - 718
  • [8] Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants
    Azam, Faizul
    Alkskas, Ismail A.
    Khokra, Sukhbir Lal
    Prakash, Om
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (01) : 203 - 211
  • [9] PHENETHYLTHIAZOLETHIOUREA (PETT) COMPOUNDS, A NEW CLASS OF HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS .1. SYNTHESIS AND BASIC STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF PETT ANALOGS
    BELL, FW
    CANTRELL, AS
    HOGBERG, M
    JASKUNAS, SR
    JOHANSSON, NG
    JORDAN, CL
    KINNICK, MD
    LIND, P
    MORIN, JM
    NOREEN, R
    OBERG, B
    PALKOWITZ, JA
    PARRISH, CA
    PRANC, P
    SAHLBERG, C
    TERNANSKY, RJ
    VASILEFF, RT
    VRANG, L
    WEST, SJ
    ZHANG, H
    ZHOU, XX
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (25) : 4929 - 4936
  • [10] Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring
    Bharti, S. K.
    Nath, G.
    Tilak, R.
    Singh, S. K.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (02) : 651 - 660
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