Recent developments of 2-aminothiazoles in medicinal chemistry

被引：189

作者：

Das, Debasis ^{[1
]}

Sikdar, Papiya ^{[1
]}

Bairagi, Moumita ^{[1
]}

机构：

[1] Sree Chaitanya Coll, Post Grad Dept Chem, Habra 743268 24, Parganas, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 109卷

关键词：

2-Aminothiazole; Thiazole; Review; Bioactive; Drugs; Medicinal chemistry; Pharmacological activity; CYCLIN-DEPENDENT KINASE; IN-VITRO ACTIVITY; BIOLOGICAL EVALUATION; SCHIFF-BASES; DERIVATIVES; DISCOVERY; INHIBITORS; DESIGN; THIAZOLES; AGENTS;

D O I：

10.1016/j.ejmech.2015.12.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 2-aminothiazole (2-AT) core is an active pharmacophore and used in medicinal chemistry and drug discovery research. A number of drugs with 2-AT core are in the market, e.g. Famotidine, Cefdinir, Meloxcam etc. Recently, 2-AT core has been explored for many more important therapeutic areas and identified new 2-aminothiazoles with anticancer, antitumor, antidiebatic and anticonvulsant activity. In this review, we discuss the newly identified and developed 2-aminothiazoles in recent years and their use in medicinal chemistry and pharmacology. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：89 / 98

页数：10

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