IgG Fc receptor polymorphisms in human disease: Implications for intravenous immunoglobulin therapy

被引：153

作者：

Binstadt, BA

Geha, RS

Bonilla, FA

机构：

[1] Childrens Hosp, Div Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2003年 / 111卷 / 04期

关键词：

autoimmune; Fc receptor; Guillain-Barre; intravenous immunoglobulin; ITP lupus; multiple sclerosis; polymorphism; vasculitis;

D O I：

10.1067/mai.2003.1380

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Polymorphisms of human Fc receptors (FcRs) have been described that are associated with the development or progression of autoimmune diseases. The FcR polymorphisms affect the affinity with which FcRs interact with immunoglobulin molecules. Intravenous immunoglobulin is administered as therapy for many autoimmune diseases and might exert its effects by interacting with FcRs. Thus, FcR polymorphisms might influence the efficacy of intravenous immunoglobulin therapy for patients with certain autoimmune diseases. In this article we review FcR polymorphisms in relation to autoimmune diseases for which intravenous immunoglobulin is used therapeutically.

引用

页码：697 / 703

页数：7

共 77 条

[1] INTRAVENOUS IMMUNOGLOBULIN TREATMENT OF EXPERIMENTAL T-CELL-MEDIATED AUTOIMMUNE-DISEASE - UP-REGULATION OF T-CELL PROLIFERATION AND DOWN-REGULATION OF TUMOR-NECROSIS-FACTOR-ALPHA SECRETION [J].