The callipyge locus:: evidence for the trans interaction of reciprocally imprinted genes

被引：121
作者：
Georges, M
Charlier, C
Cockett, N
机构：
[1] Univ Liege, Fac Vet Med, Dept Genet, B-4000 Liege, Belgium
[2] Utah State Univ, Coll Agr, Dept Anim Dairy & Vet Sci, Logan, UT 84322 USA
来源：
TRENDS IN GENETICS | 2003年 / 19卷 / 05期
关键词：
D O I：
10.1016/S0168-9525(03)00082-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The callipyge phenotype in sheep is an inherited muscular hypertrophy that affects only heterozygous individuals who receive the CLPG mutation from their father. The CLPG mutation is a single nucleotide substitution in what is probably a long-range control element (LRCE) within the DLK1-GTL2 imprinted domain. Recent results suggest that the unique mode of inheritance of callipyge, referred to as polar overdominance, results from the combination of the cis-effect of the CLPG mutation on the expression levels of genes in the DLK1-GTL2 imprinted domain, and the trans interaction between the products of reciprocally imprinted genes.
引用
收藏
页码：248 / 252
页数：5
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