Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells

被引：67
作者：
Wang, Zhiqiang [1 ]
Sun, Peng [1 ]
Gao, Chun [1 ]
Chen, Ji [1 ]
Li, Jun [1 ]
Chen, Zhonghao [1 ]
Xu, Ming [1 ]
Shao, Jun [1 ]
Zhang, Yunpeng [1 ]
Xie, Jiang [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gen, 1111 Xian Xia Rd, Shanghai, Peoples R China
来源：
EXPERIMENTAL CELL RESEARCH | 2017年 / 357卷 / 01期
关键词：
Colon cancer; LRP1B; Beta-catenin/TCF signaling; Cell growth and migration; BETA-CATENIN/TCF; MUTATION; PATHWAY; GENE; APC; EXPRESSION; COMPLEX; FAMILY; MICE;
D O I：
10.1016/j.yexcr.2017.04.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aberrant activation of beta-catenin/TCF signaling is one of the hallmarks of colon cancer. It is of great interest to study the mechanism for the regulation of beta-catenin/TCF signaling. In this study, it was found that LRP1B was down-regulated in colon cancer tissues and inhibited the growth, migration and metastasis of colon cancer cells. The molecular mechanism study revealed that LRP1B interacted with DVL2, inhibited the interaction between DVL2 and Axin, and negatively regulated beta-catenin/TCF signaling. Taken together, our study demonstrated the suppressive roles of LRP1B in the progression of colon cancer, implicating that restoring the function of LRP1B would be a promising strategy for the treatment of colon cancer.
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收藏
页码：1 / 8
页数：8
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