BCG Vaccine Protection Against Mycobacterium tuberculosis Infection by Level of Exposure in The Gambia

被引：3

作者：

Campbell, Nicola ^{[1
]}

Verrall, Ayesha J. ^{[2
]}

Donkor, Simon ^{[3
]}

Sutherland, Jayne S. ^{[3
]}

Hill, Philip C. ^{[1
]}

机构：

[1] Univ Otago, Ctr Int Hlth, Otago Med Sch, Dunedin, New Zealand

[2] Univ Otago, Dept Pathol & Mol Med, Wellington, New Zealand

[3] MRC Unit Gambia LSHTM, Vaccines & Immun Theme, TB Res Grp, Fajara, Gambia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 223卷 / 04期

基金：

英国医学研究理事会;

关键词：

BCG vaccine; tuberculosis; exposure; protection;

D O I：

10.1093/infdis/jiaa411

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In Indonesia, BCG vaccine protection against Mycobacterium tuberculosis infection decreased with increasing exposure to the pathogen. We aimed to validate these findings in Africa. Poisson regression was used to estimate BCG protection, stratified by pathogen exposure using an exposure score, against enzyme-linked immunospot assay conversion at 3 months in 220 Gambian case contacts. Although the interaction between BCG and exposure was not significant (P=.13), BCG protection was strongest in the lowest-exposure tertile (relative risk, 0.35 [95% confidence interval, .15-.82; P=.02] vs 0.50 [.30-.83; P=.008] and 0.71 (.45-1.13; P=.1] for the middle and highest-exposure tertiles, respectively. These results are consistent with those from Indonesia.

引用

页码：719 / 720

页数：2

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