Bone Targeted Delivery of SDF-1 via Alendronate Functionalized Nanoparticles in Guiding Stem Cell Migration

被引：56
作者：
Chen, Qingchang [1 ]
Zheng, Chuping [1 ,3 ]
Li, Yanqun [1 ]
Bian, Shaoquan [1 ]
Pan, Haobo [1 ]
Zhao, Xiaoli [1 ]
Lu, William W. [2 ]
机构：
[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Res Ctr Human Tissues & Organs Degenerat, Shenzhen 518055, Peoples R China
[2] Univ Hong Kong, Dept Orthopaed & Traumatol, 21 Sassoon Rd, Hong Kong 999077, Hong Kong, Peoples R China
[3] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangzhou 511436, Guangdong, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2018年 / 10卷 / 28期
基金：
中国国家自然科学基金;
关键词：
bone targeting; gene delivery; stem cell homing; SDF-1; osteoporosis therapy; POLY(ETHYLENE GLYCOL); MESENCHYMAL CELLS; GENE-TRANSFER; FACTOR-I; RESORPTION; THERAPY; PEPTIDE; REPAIR; TRANSPLANTATION; TRAFFICKING;
D O I：
10.1021/acsami.8b08606
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Stem cells are well-known for their great capacity for tissue regeneration. This provides a promising source for cell-based therapies in treating various bone degenerative disorders. However, the major hurdles for their application in transplantation are the poor bone marrow homing and engraftment efficiencies. Stromal cell-derived factor 1 (SDF-1) has been identified as a major stem cell homing factor. With the aims of bone targeted SDF-1 delivery and regulating MSCs migration, alendronate modified liposomal nanoparticles (Aln-Lipo) carrying SDF-1 gene were developed in this study. Alendronate modification significantly increased the mineral binding affinity of liposomes, and facilitated the gene delivery to osteoblastic cells. Up-regulated SDF-1 expression in osteoblasts triggered MSCs migration. Systemic infusion of Aln-Lipo-SDF-1 with fluorescence labeling in mice showed the accumulation in osseous tissue by biophotonic imaging. Corresponding to the delivered SDF-1, the transplanted GFP+ MSCs were attracted to bone marrow and contributed to bone regeneration. This study may provide a useful technique in regulating stem cell migration.
引用
收藏
页码：23700 / 23710
页数：11
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