Polyacrylic resins regulate transcriptional control of interleukin-6, gp80, and gp130 genes in human gingival fibroblasts

被引：7

作者：

Borelli, Bruna ^{[1
]}

Zarone, Fernando ^{[1
]}

Rivieccio, Virginia ^{[1
]}

Riccitiello, Francesco ^{[1
]}

Simeone, Michele ^{[1
]}

Sorrentino, Roberto ^{[1
]}

Rengo, Sandro ^{[1
]}

Spagnuolo, Gianrico ^{[1
]}

Procino, Alfredo ^{[1
]}

机构：

[1] Univ Naples Federico II, Med Sch, Dept Neurosci Reprod & Odontostomatol Sci, Via S Pansini 5, I-80131 Naples, Italy

来源：

JOURNAL OF ORAL SCIENCE | 2017年 / 59卷 / 01期

关键词：

inflammation; interleukin-6; cytotoxicity; cell culture; cytokines; C-REACTIVE PROTEIN; CARDIOVASCULAR MORTALITY; RELEASE; PREDICTION; CYTOKINES; POLYMERS; NECROSIS; DISEASE; CELLS; WOMEN;

D O I：

10.2334/josnusd.16-0388

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Studies have failed to identify the molecular mechanisms that regulate the genotoxic and cytotoxic effects of methacrylate resins, which are important in the biocompatibility of dental materials. Interleukin (IL)-6 has a crucial role in the control of acute-phase protein response during inflammation. In humans, the synthesis and release of two major acute-phase proteins, C-reactive protein and serum amyloid A, are regulated by IL-6. This study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation.

引用

页码：87 / 91

页数：5

共 23 条

[1] Bhola Rahul., 2010, Trends in Biomaterials and Artificial Organ, V23, P129
[2] Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells
Calabró, P
Willerson, JT
Yeh, ETH
[J]. CIRCULATION, 2003, 108 (16) : 1930 - 1932
[3] Long-Term Fluoride Release from Dental Resins Affects STRO-1+ Cell Behavior
Calarco, A.
Di Salle, A.
Tammaro, L.
De Luca, I.
Mucerino, S.
Petillo, O.
Riccitiello, F.
Vittoria, V.
Peluso, G.
[J]. JOURNAL OF DENTAL RESEARCH, 2015, 94 (08) : 1099 - 1105
[4] The effect of heat- and auto-polymerized denture base polymers on clonogenicity, apoptosis, and necrosis in fibroblasts: denture base polymers induce apoptosis and necrosis
Cimpan, MR
Matre, R
Cressey, LI
Tysnes, B
Lie, SA
Gjertsen, BT
Skaug, N
[J]. ACTA ODONTOLOGICA SCANDINAVICA, 2000, 58 (05) : 217 - 228
[5] Pro-inflammatory cytokine release and cell growth inhibition in primary human oral cells after exposure to endodontic sealer
Diomede, F.
Caputi, S.
Merciaro, I.
Frisone, S.
D'Arcangelo, C.
Piattelli, A.
Trubiani, O.
[J]. INTERNATIONAL ENDODONTIC JOURNAL, 2014, 47 (09) : 864 - 872
[6] Body mass index, diabetes, and C-reactive protein among US adults
Ford, ES
[J]. DIABETES CARE, 1999, 22 (12) : 1971 - 1977
[7] Frazer Robert Q, 2005, J Long Term Eff Med Implants, V15, P629
[8] Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
Heinrich, PC
Behrmann, I
Müller-Newen, G
Schaper, F
Graeve, L
[J]. BIOCHEMICAL JOURNAL, 1998, 334 : 297 - 314
[9] Role of systemic markers in periodontal diseases: A possible inflammatory burden and risk factor for cardiovascular diseases
Kalburgi, V
Sravya, L.
Warad, S.
Vijayalaxmi, K.
Sejal, P.
Hazeil, D. J.
[J]. ANNALS OF MEDICAL AND HEALTH SCIENCES RESEARCH, 2014, 4 (03) : 388 - 392
[10] Cytokines and chemokines are differentially expressed in patients with periodontitis: Possible role for TGF-β1 as a marker for disease progression
Khalaf, Hazem
Lonn, Johanna
Bengtsson, Torbjorn
[J]. CYTOKINE, 2014, 67 (01) : 29 - 35

← 1 2 3 →