Cholinesterase inhibitory constituents from Onosma hispida

被引：38

作者：

Ahmad, I ^{[1
]}

Anis, I ^{[1
]}

Malik, A ^{[1
]}

Nawaz, SA ^{[1
]}

Choudhary, MI ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 04期

关键词：

Onosma hispida; Boraginaceae; flavanone; cholinesterase inhibitor;

D O I：

10.1248/cpb.51.412

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hispidone, a new flavanone, has been isolated from Onosma hispida and assigned the structure (2S)-5,2'-di-hydroxy-7,4',5'-trimethoxyflavanone (1) by spectroscopic methods. In addition, (2S)-5,2'-dihydroxy-7,5'-dimethoxyflavanone (2), benzoic acid (3), and 4-hydroxy benzoic acid (4) are also reported for the first time from this species.

引用

页码：412 / 414

页数：3

共 15 条

[1] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].

BARTUS, RT ;

DEAN, RL ;

BEER, B ;

LIPPA, AS .

SCIENCE, 1982, 217 (4558) :408-417

[2] NEW FLAVONOIDS FROM INULA-CAPPA [J].

BARUAH, NC ;

SHARMA, RP ;

THYAGARAJAN, G ;

HERZ, W ;

GOVINDAN, SV .

PHYTOCHEMISTRY, 1979, 18 (12) :2003-2006

[3] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[4]

GEORGE W, 1972, DICT EC PRODUCTS IND, V5, P486

[5]

Hai M.A., 1995, J BANGLADESH CHEM SO, V8, P139

[6] 3 2',4',6'-TRIOXYGENATED FLAVANONES IN ROOTS OF ECHINOSOPHORA-KOREENSIS [J].

IINUMA, M ;

OHYAMA, M ;

TANAKA, T ;

MIZUNO, M ;

HONG, SK .

PHYTOCHEMISTRY, 1992, 31 (02) :665-669

[7] 7 PHENOLIC-COMPOUNDS IN THE ROOTS OF SOPHORA-EXIGUA [J].

IINUMA, M ;

YOKOYAMA, J ;

OHYAMA, M ;

TANAKA, T ;

MIZUNO, M ;

RUANGRUNGSI, N .

PHYTOCHEMISTRY, 1993, 33 (01) :203-208

[8]

KHAJURIA RK, 1993, INDIAN J CHEM B, V32, P390

[9]

Mabry TJ, 1972, The Systematic Identification of flavonoids

[10]

Mellidis A.S., 1998, CHEM CHRON, V17, P67

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