Hypertriglyceridemia: A Neglected Risk Factor for Ischemic Stroke?

被引：32
作者：
Liang, Hai-jie [1 ,2 ]
Zhang, Qing-yi [1 ,2 ,3 ,4 ,5 ]
Hu, Yi-tong [1 ,2 ]
Liu, Guo-qing [2 ]
Qi, Rong [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Sch Basic Med Sci, Dept Pharmacol, Beijing, Peoples R China
[2] Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
[3] State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
[4] NHC Key Lab Cardiovasc Mol Biol & Regulatory Pept, Beijing, Peoples R China
[5] Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Hlth Sci Ctr, Beijing, Peoples R China
来源：
JOURNAL OF STROKE | 2022年 / 24卷 / 01期
关键词：
Hypertriglyceridemia; Ischemic stroke; Incidence; Prognosis; TRIGLYCERIDE-RICH LIPOPROTEINS; C-REACTIVE PROTEIN; PLASMINOGEN-ACTIVATOR INHIBITOR-1; INTIMA-MEDIA THICKNESS; INDUCED MONOCYTE ADHESION; VEIN ENDOTHELIAL-CELLS; CORONARY-HEART-DISEASE; COAGULATION FACTOR-VII; NONFASTING TRIGLYCERIDES; METABOLIC SYNDROME;
D O I：
10.5853/jos.2021.02831
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Hypertriglyceridemia is caused by defects in triglyceride metabolism and generally manifests as abnormally high plasma triglyceride levels. Although the role of hypertriglyceridemia may not draw as much attention as that of plasma cholesterol in stroke, plasma triglycerides, especially nonfasting triglycerides, are thought to be correlated with the risk of ischemic stroke. Hypertriglyceridemia may increase the risk of ischemic stroke by promoting atherosclerosis and thrombosis and increasing blood viscosity. Moreover, hypertriglyceridemia may have some protective effects in patients who have already suffered a stroke via unclear mechanisms. Therefore, further studies are needed to elucidate the role of hypertriglyceridemia in the development and prognosis of ischemic stroke.
引用
收藏
页码：21 / 40
页数：20
相关论文
共 50 条
[21]   Hyperhomocysteinemia as a risk factor for ischemic stroke: an Indian scenario [J].
Modi, M ;
Prabhakar, S ;
Majumdar, S ;
Khullar, M ;
Lal, V ;
Das, CP .
NEUROLOGY INDIA, 2005, 53 (03) :297-301
[22]   Is lipoprotein(a) a risk factor for ischemic stroke and venous thromboembolism? [J].
Nave A.H. ;
von Eckardstein A. .
Clinical Research in Cardiology Supplements, 2019, 14 (Suppl 1) :28-32
[23]   Kalirin: a novel genetic risk factor for ischemic stroke [J].
Krug, Tiago ;
Manso, Helena ;
Gouveia, Liliana ;
Sobral, Joao ;
Xavier, Joana M. ;
Albergaria, Isabel ;
Gaspar, Gisela ;
Correia, Manuel ;
Viana-Baptista, Miguel ;
Simoes, Rita Moiron ;
Pinto, Amelia Nogueira ;
Taipa, Ricardo ;
Ferreira, Carla ;
Fontes, Joao Ramalho ;
Silva, Mario Rui ;
Gabriel, Joao Paulo ;
Matos, Ilda ;
Lopes, Gabriela ;
Ferro, Jose M. ;
Vicente, Astrid M. ;
Oliveira, Sofia A. .
HUMAN GENETICS, 2010, 127 (05) :513-523
[24]   Is diabetic retinopathy an independent risk factor for ischemic stroke? [J].
Cheung, Ning ;
Rogers, Sophie ;
Couper, David J. ;
Klein, Ronald ;
Sharrett, A. Richey ;
Wong, Tien Y. .
STROKE, 2007, 38 (02) :398-401
[25]   Angiotensinogen gene polymorphism as a risk factor for ischemic stroke [J].
Nakase, Taizen ;
Mizuno, Toshiki ;
Harada, Sanae ;
Yamada, Kei ;
Nishimura, Tsunehiko ;
Ozasa, Kotaro ;
Watanabe, Yoshiyuki ;
Nagata, Ken .
JOURNAL OF CLINICAL NEUROSCIENCE, 2007, 14 (10) :943-947
[26]   Chronic HCV infection is a risk factor of ischemic stroke [J].
Adinolfi, Luigi E. ;
Restivo, Luciano ;
Guerrera, Barbara ;
Sellitto, Ausilio ;
Ciervo, Antonella ;
Iuliano, Natalina ;
Rinaldi, Luca ;
Santoro, Aldo ;
Vigni, Giovanni Li ;
Marrone, Aldo .
ATHEROSCLEROSIS, 2013, 231 (01) :22-26
[27]   Association between CRP polymorphisms and the risk of ischemic stroke [J].
Huang, Juan ;
He, Qingchuan ;
Yang, Shibin ;
Jiang, Wei ;
Xu, Lili ;
Wang, Jieping ;
Jian, Rui ;
Xu, Fangyuan .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (02) :2241-2246
[28]   The Clinical Features of Ischemic Stroke Patients for Whom Smoking Was Considered the Sole Risk Factor for Ischemic Stroke [J].
Fukuoka, Takuya ;
Nakazato, Yoshihiko ;
Kawasaki, Hitoshi ;
Ikeda, Kei ;
Furuya, Tomotsugu ;
Miyake, Akifumi ;
Mitsufuji, Takashi ;
Ito, Yasuo ;
Takahashi, Kazushi ;
Araki, Nobuo ;
Tahahashi, Norio ;
Yamamoto, Toshimasa .
INTERNAL MEDICINE, 2018, 57 (12) :1703-1706
[29]   Anemia Is a Risk Factor for the Development of Ischemic Stroke and Post-Stroke Mortality [J].
Heo, Jayoon ;
Youk, Tae-Mi ;
Seo, Kwon-Duk .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (12)
[30]   Hypertriglyceridemia in an outpatient department - Significance as an atherosclerotic risk factor [J].
Scholz, M. ;
Tselmin, S. ;
Fischer, S. ;
Julius, U. .
ATHEROSCLEROSIS SUPPLEMENTS, 2015, 18 :146-153
12345