Long non-coding RNA BBOX1-AS1 exacerbates esophageal squamous cell carcinoma development by regulating HOXB7/β-catenin axis

被引：9
作者：
Sheng, Jinxiu [1 ,2 ]
Zhou, Mingxia [3 ]
Wang, Chang [1 ,2 ]
Jia, Jinlin [1 ,2 ]
Chu, Jie [1 ,2 ]
Ju, Chenxi [1 ,2 ]
Wan, Junhu [1 ,2 ]
He, Jing [4 ]
He, Fucheng [1 ,2 ]
机构：
[1] Zhengzhou Univ, Dept Med Lab, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China
[2] Key Clin Lab Henan Prov, Zhengzhou 450052, Henan, Peoples R China
[3] Zhengzhou Univ, Dept Gastroenterol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China
[4] Zhengzhou Univ, Dept Breast Surg, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China
来源：
EXPERIMENTAL CELL RESEARCH | 2022年 / 415卷 / 01期
关键词：
Esophageal squamous cell carcinoma; Long non-coding RNA; BBOX1-AS1; HOXB7; beta-catenin; CANCER; PROGRESSION; LNCRNA; HOXB7;
D O I：
10.1016/j.yexcr.2022.113117
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mounting evidence suggests that long non-coding RNAs play a critical role in the occurrence and development of human malignancies. Nonetheless, it remains unknown whether Gamma-Butyrobetaine Hydroxylase 1-Antisense RNA 1 (BBOX1-AS1) participates in the regulation of esophageal squamous cell carcinoma (ESCC) carcinogenesis. Herein, we validated that BBOX1-AS1 was notably overexpressed in ESCC tissues compared to the adjacent non-tumor tissues and significantly correlated with tumor sizes. BBOX1-AS1 enhanced the malignant behavior of ESCC cells in vitro, such as cell proliferation, migration, and invasion. In addition, knockdown of BBOX1-AS1 augmented the proportion of apoptotic cells in ESCC cells. Mechanistically, BBOX1-AS1 regulated HOXB7 expression, and rescue experiments indicated that silencing of HOXB7 could abolish the malignant phenotypes mediated by BBOX1-AS1 to a certain extent. Moreover, HOXB7 participated in the activation of the Wnt/ beta-catenin signaling pathway. In summary, our findings substantiated that BBOX1-AS1 could activate the Wnt/ beta-catenin pathway by upregulating HOXB7 expression to promote ESCC progression, providing a rationale to develop novel therapeutic approaches.
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页数：11
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