Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities

被引：83

作者：

Dou, Man ^{[1
,3
]}

Di, Lei ^{[1
]}

Zhou, Li-Li ^{[2
]}

Yan, Yong-Ming ^{[1
,4
]}

Wang, Xin-Long ^{[1
]}

Zhou, Feng-Jiao ^{[1
]}

Yang, Zhu-Liang ^{[5
]}

Li, Rong-Tao ^{[3
]}

Hou, Fan-Fan ^{[2
]}

Cheng, Yong-Xian ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Southern Med Univ, Nanfang Hosp, Div Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China

[3] Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[5] Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 23期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/ol502806j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)- and (-)-cochlearols A (1) and B (2), two meroterpenoids with novel polycyclic skeletons, were isolated from the fruiting bodies of the fungus Ganoderma cochlear. Their structures and stereochemistry were determined by using spectroscopic, computational and single-crystal X-ray diffraction methods. Cochlearol A is a new normeroterpenoid containing a naturally unusual dioxaspiro[4.5]decane motif. Biological studies showed that (-)-2 is a strong inhibitor of p-Smads, exhibiting renoprotective activities in TGF-beta 1 induced rat renal proximal tubular cells.

引用

页码：6064 / 6067

页数：4

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