Encapsulation of cannabinoid drugs in nanostructured lipid carriers

被引：42

作者：

Esposito, Elisabetta ^{[1
]}

Drechsler, Markus ^{[2
]}

Cortesi, Rita ^{[1
]}

Nastruzzi, Claudio ^{[1
]}

机构：

[1] Univ Ferrara, Dept Life Sci & Biotechnol, I-44121 Ferrara, Italy

[2] Univ Bayreuth, BIMF Soft Matter Electronmicroscopy, Bayreuth, Germany

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2016年 / 102卷

关键词：

Nanostructured lipid carriers; Cannabinoid drugs; Cryo-TEM; NANOPARTICLES; RIMONABANT; DELIVERY; RECEPTOR;

D O I：

10.1016/j.ejpb.2016.03.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study describes the development and optimization of a method to encapsulate the potent and expensive cannabinoids drugs in nanostructured lipid carriers; namely, URB597, AM251 and rimonabant have been considered. NLC production by melt and ultrasonication protocol has been specifically designed to optimize nanoparticle recovery and drug encapsulation efficiency. Special care has been devoted to the modality of oil and water phase emulsification and the entire production has been studied and discussed. NLC recovery, morphology, dimensional distribution and encapsulation efficiency are presented. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：87 / 91

页数：5

共 10 条

[1] AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion [J].

Chambers, AP ;

Koopmans, HS ;

Pittman, QJ ;

Sharkey, KA .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 147 (01) :109-116

[2] Solid lipid nanoparticles as delivery systems for bromocriptine [J].

Esposito, Elisabetta ;

Fantin, Martina ;

Marti, Matteo ;

Drechsler, Markus ;

Paccamiccio, Lydia ;

Mariani, Paolo ;

Sivieri, Elisa ;

Lain, Francesco ;

Menegatti, Enea ;

Morari, Michele ;

Cortesi, Rita .

PHARMACEUTICAL RESEARCH, 2008, 25 (07) :1521-1530

[3] Cannabinoid antagonist in nanostructured lipid carriers (NLCs): design, characterization and in vivo study [J].

Esposito, Elisabetta ;

Ravani, Laura ;

Drechsler, Markus ;

Mariani, Paolo ;

Contado, Catia ;

Ruokolainen, Janne ;

Ratano, Patrizia ;

Campolongo, Patrizia ;

Trezza, Viviana ;

Nastruzzi, Claudio ;

Cortesi, Rita .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 48 :328-336

[4] Clotrimazole nanoparticle gel for mucosal administration [J].

Esposito, Elisabetta ;

Ravani, Laura ;

Contado, Catia ;

Costenaro, Andrea ;

Drechsler, Markus ;

Rossi, Damiano ;

Menegatti, Enea ;

Grandini, Alessandro ;

Cortesi, Rita .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2013, 33 (01) :411-418

[5] The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein [J].

Fiori, J. L. ;

Sanghvi, M. ;

O'Connell, M. P. ;

Krzysik-Walker, S. M. ;

Moaddel, R. ;

Bernier, M. .

BRITISH JOURNAL OF PHARMACOLOGY, 2011, 164 (03) :1026-1040

[6] Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models [J].

Jayamanne, A ;

Greenwood, R ;

Mitchell, VA ;

Aslan, S ;

Piomelli, D ;

Vaughan, CW .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 147 (03) :281-288

[7] Lipid nanoparticles for parenteral delivery of actives [J].

Joshi, Medha D. ;

Mueller, Rainer H. .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2009, 71 (02) :161-172

[8]

Klein TW, 2007, ADV EXP MED BIOL, V601, P395

[9] AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies [J].

Seely, Kathryn A. ;

Brents, Lisa K. ;

Franks, Lirit N. ;

Rajasekaran, Maheswari ;

Zimmerman, Sarah M. ;

Fantegrossi, William E. ;

Prather, Paul L. .

NEUROPHARMACOLOGY, 2012, 63 (05) :905-915

[10] The endocannabinoid system and rimonabant:: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism -: or inverse agonism -: as potential obesity treatment and other therapeutic use [J].

Xie, S. ;

Furjanic, M. A. ;

Ferrara, J. J. ;

McAndrew, N. R. ;

Ardino, E. L. ;

Ngondara, A. ;

Bernstein, Y. ;

Thomas, K. J. ;

Kim, E. ;

Walker, J. M. ;

Nagar, S. ;

Ward, S. J. ;

Raffa, R. B. .

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2007, 32 (03) :209-231

← 1 →