Conserved non-genic sequences - an unexpected feature of mammalian genomes

被引：194
作者：
Dermitzakis, ET
Reymond, A
Antonarakis, SE
机构：
[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
[2] BEP, Fac Biol & Med, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland
[3] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland
来源：
NATURE REVIEWS GENETICS | 2005年 / 6卷 / 02期
关键词：
D O I：
10.1038/nrg1527
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?
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页码：151 / 157
页数：8
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