ProtVista: visualization of protein sequence annotations

被引:50
作者
Watkins, Xavier [1 ,2 ]
Garcia, Leyla J. [1 ]
Pundir, Sangya [1 ]
Martin, Maria J. [1 ]
机构
[1] EMBL EBI, Hinxton, England
[2] Open Targets Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England
[3] Univ Delaware, Prot Informat Resource, Newark, DE 19711 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1093/bioinformatics/btx120
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
ProtVista is a comprehensive visualization tool for the graphical representation of protein sequence features in the UniProt Knowledgebase, experimental proteomics and variation public data-sets. The complexity and relationships in this wealth of data pose a challenge in interpretation. Integrative visualization approaches such as provided by ProtVista are thus essential for researchers to understand the data and, for instance, discover patterns affecting function and disease associations. Availability and Implementation: ProtVista is a JavaScript component released as an open source project under the Apache 2 License. Documentation and source code are available at http://ebi-uniprot.github.io/ProtVista/. Contact:martin@ebi.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.
引用
收藏
页码:2040 / 2041
页数:2
相关论文
共 6 条
[1]   A method and server for predicting damaging missense mutations [J].
Adzhubei, Ivan A. ;
Schmidt, Steffen ;
Peshkin, Leonid ;
Ramensky, Vasily E. ;
Gerasimova, Anna ;
Bork, Peer ;
Kondrashov, Alexey S. ;
Sunyaev, Shamil R. .
NATURE METHODS, 2010, 7 (04) :248-249
[2]   The EBI enzyme portal [J].
Alcantara, Rafael ;
Onwubiko, Joseph ;
Cao, Hong ;
de Matos, Paula ;
Cham, Jennifer A. ;
Jacobsen, Jules ;
Holliday, Gemma L. ;
Fischer, Julia D. ;
Rahman, Syed Asad ;
Jassal, Bijay ;
Goujon, Mikael ;
Rowland, Francis ;
Velankar, Sameer ;
Lopez, Rodrigo ;
Overington, John P. ;
Kleywegt, Gerard J. ;
Hermjakob, Henning ;
O'Donovan, Claire ;
Martin, Maria Jesus ;
Thornton, Janet M. ;
Steinbeck, Christoph .
NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) :D773-D780
[3]   UniProt: a hub for protein information [J].
Bateman, Alex ;
Martin, Maria Jesus ;
O'Donovan, Claire ;
Magrane, Michele ;
Apweiler, Rolf ;
Alpi, Emanuele ;
Antunes, Ricardo ;
Arganiska, Joanna ;
Bely, Benoit ;
Bingley, Mark ;
Bonilla, Carlos ;
Britto, Ramona ;
Bursteinas, Borisas ;
Chavali, Gayatri ;
Cibrian-Uhalte, Elena ;
Da Silva, Alan ;
De Giorgi, Maurizio ;
Dogan, Tunca ;
Fazzini, Francesco ;
Gane, Paul ;
Cas-tro, Leyla Garcia ;
Garmiri, Penelope ;
Hatton-Ellis, Emma ;
Hieta, Reija ;
Huntley, Rachael ;
Legge, Duncan ;
Liu, Wudong ;
Luo, Jie ;
MacDougall, Alistair ;
Mutowo, Prudence ;
Nightin-gale, Andrew ;
Orchard, Sandra ;
Pichler, Klemens ;
Poggioli, Diego ;
Pundir, Sangya ;
Pureza, Luis ;
Qi, Guoying ;
Rosanoff, Steven ;
Saidi, Rabie ;
Sawford, Tony ;
Shypitsyna, Aleksandra ;
Turner, Edward ;
Volynkin, Vladimir ;
Wardell, Tony ;
Watkins, Xavier ;
Zellner, Hermann ;
Cowley, Andrew ;
Figueira, Luis ;
Li, Weizhong ;
McWilliam, Hamish .
NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) :D204-D212
[4]  
Corpas Manuel, 2014, F1000Res, V3, P55, DOI 10.12688/f1000research.3-55.v1
[5]   Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm [J].
Kumar, Prateek ;
Henikoff, Steven ;
Ng, Pauline C. .
NATURE PROTOCOLS, 2009, 4 (07) :1073-1082
[6]   SEQUENCE LOGOS - A NEW WAY TO DISPLAY CONSENSUS SEQUENCES [J].
SCHNEIDER, TD ;
STEPHENS, RM .
NUCLEIC ACIDS RESEARCH, 1990, 18 (20) :6097-6100