Mitochondrial pharmacogenomics: barcode for antibiotic therapy

被引：38

作者：

Pacheu-Grau, David ^{[1
]}

Gomez-Duran, Aurora ^{[1
]}

Lopez-Perez, Manuel J. ^{[1
]}

Montoya, Julio ^{[1
]}

Ruiz-Pesini, Eduardo ^{[1
,2
]}

机构：

[1] Univ Zaragoza, Inst Aragones Ciencias Salud, Ctr Invest Biomed Red Enfermedades Raras, Dept Bioquim Biol Mol & Celular, E-50013 Zaragoza, Spain

[2] Univ Zaragoza, Fdn Aragon ID, E-50013 Zaragoza, Spain

来源：

DRUG DISCOVERY TODAY | 2010年 / 15卷 / 1-2期

关键词：

12S RIBOSOMAL-RNA; PEPTIDYL TRANSFERASE CENTER; TRANSCRIPTION FACTOR B1; STRUCTURAL BASIS; HEARING-LOSS; PROTEIN-SYNTHESIS; C1494T MUTATION; GENE; RESISTANCE; MTDNA;

D O I：

10.1016/j.drudis.2009.10.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ribosomal RNA (rRNA)-targeting drugs inhibit protein synthesis and represent effective antibiotics for the treatment of infectious diseases. Given the bacterial origins of mitochondria, the molecular and structural components of the protein expression system are much alike. Moreover, the mutational rate of mitochondrial rRNAs is higher than that of nuclear rRNAs, and some of these mutations might simulate the microorganism's rRNA structure. Consequently, individuals become more susceptible to antibiotics, the mitochondrial function is affected and toxic effects appear. Systems are available to analyze the interaction between antibiotics and mitochondrial DNA genetic variants, thus making a pharmacogenomic approach to antibiotic therapy possible.

引用

页码：33 / 39

页数：7

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