Genetic risk for Alzheimer's disease, cognition, and mild behavioral impairment in healthy older adults

被引：47

作者：

Creese, Byron ^{[1
]}

Arathimos, Ryan ^{[2
]}

Brooker, Helen ^{[1
]}

Aarsland, Dag ^{[3
,4
]}

Corbett, Anne ^{[1
]}

Lewis, Cathryn ^{[2
]}

Ballard, Clive ^{[1
]}

Ismail, Zahinoor ^{[1
,5
,6
,7
,8
]}

机构：

[1] Univ Exeter, Coll Med & Hlth, Med Sch, RILD Bldg,Barrack Rd, Exeter EX2 5AX, Devon, England

[2] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Old Age Psychiat, London, England

[4] Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway

[5] Univ Calgary, Hotchkiss Brain Inst, Dept Psychiat, Calgary, AB, Canada

[6] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB, Canada

[7] Univ Calgary, Hotchkiss Brain Inst, Dept Community Hlth Sci, Calgary, AB, Canada

[8] Univ Calgary, OBrien Inst Publ, Calgary, AB, Canada

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2021年 / 13卷 / 01期

基金：

英国医学研究理事会;

关键词：

Alzheimer' s disease; cognition; mild behavioral impairment; neuropsychiatric symptoms; polygenic score; NEUROPSYCHIATRIC SYMPTOMS; POLYGENIC RISK; DEMENTIA; NEURODEGENERATION; STRATIFICATION; DEPRESSION; CONVERSION; DECLINE; ABILITY; SCORE;

D O I：

10.1002/dad2.12164

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background The neuropsychiatric syndrome mild behavioral impairment (MBI) describes an at-risk state for dementia and may be a useful screening tool for sample enrichment. We hypothesized that stratifying a cognitively normal sample on MBI status would enhance the association between genetic risk for Alzheimer's disease (AD) and cognition. Methods Data from 4458 participants over age 50 without dementia was analyzed. A cognitive composite score was constructed and the MBI Checklist was used to stratify those with MBI and those without. Polygenic scores for AD were generated using summary statistics from the IGAP study. Results AD genetic risk was associated with worse cognition in the MBI group but not in the no MBI group (MBI: beta = -0.09, 95% confidence interval: -0.13 to -0.03, P = 0.002, R-2 = 0.003). The strongest association was in those with more severe MBI aged >= 65. Conclusions MBI is an important feature of aging; screening on MBI may be a useful sample enrichment strategy for clinical research.

引用

页数：10

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