Resistance mutations in subtype CHIV type 1 isolates from Indian patients of mumbai receiving NRTIs plus NNRTIs and experiencing a treatment failure: Resistance to AR

被引：42
作者：
Deshpande, Alaka
Jauvin, Valerie
Magnin, Noel
Pinson, Patricia
Faure, Muriel
Masquelier, Bernard
Aurillac-Lavignolle, Valerie
Fleury, Herve J. [1 ]
机构：
[1] Univ Bordeaux 2, Lab Virol EA 2968, F-33076 Bordeaux, France
[2] Grant Med Coll, Bombay, Maharashtra, India
[3] Sir JJ Hosp, Bombay, Maharashtra, India
[4] INSERM, U593, Bordeaux, France
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2007年 / 23卷 / 02期
关键词：
D O I：
10.1089/aid.2006.0183
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We present here the first data available on resistance to nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in India. In these subtype C isolates, we have observed most of the mutations noted in reverse transcriptase (RT) for subtype B with some additional substitutions ( at positions 98, 203, 208, and 221) that will warrant attention in the algorithms used.
引用
收藏
页码：335 / 340
页数：6
相关论文
共 13 条
[1]   A V106M mutation in HIV-1 clade C viruses exposed to efavirenz confers cross-resistance to non-nucleoside reverse transcriptase inhibitors [J].
Brenner, B ;
Turner, D ;
Oliveira, M ;
Moisi, D ;
Detorio, M ;
Carobene, M ;
Marlink, RG ;
Schapiro, J ;
Roger, M ;
Wainberg, MA .
AIDS, 2003, 17 (01) :F1-F5
[2]  
Deshpande A, 2004, AIDS RES HUM RETROV, V20, P1032, DOI 10.1089/aid.2004.20.1032
[3]  
DESHPANDE A, 2004, 15 AIDS C BANGK THAI
[4]   Susceptibility to antiretroviral drugs of CRF01_AE, CRF02_AG, and subtype C viruses from untreated patients of Africa and Asia: Comparative genotypic and phenotypic data [J].
Fleury, HJ ;
Toni, T ;
Lan, NTH ;
Hung, PV ;
Deshpande, A ;
Recordon-Pinson, P ;
Boucher, S ;
Lazaro, E ;
Jauvin, V ;
Lavignolle-Aurillac, V ;
Lebel-Binay, S ;
Cheret, A ;
Masquelier, B .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2006, 22 (04) :357-366
[5]   Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors [J].
Gonzales, MJ ;
Wu, TD ;
Taylor, J ;
Belitskaya, F ;
Kantor, R ;
Israelski, D ;
Chou, S ;
Zolopa, AR ;
Fessel, WJ ;
Shafer, RW .
AIDS, 2003, 17 (06) :791-799
[6]   Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration [J].
Kantor, R ;
Katzenstein, DA ;
Efron, B ;
Carvalho, AP ;
Wynhoven, B ;
Cane, P ;
Clarke, J ;
Sirivichayakul, S ;
Soares, MA ;
Snoeck, J ;
Pillay, C ;
Rudich, H ;
Rodrigues, R ;
Holguin, A ;
Ariyoshi, K ;
Bouzas, MB ;
Cahn, P ;
Sugiura, W ;
Soriano, V ;
Brigido, LF ;
Grossman, Z ;
Morris, L ;
Vandamme, AM ;
Tanuri, A ;
Phanuphak, P ;
Weber, JN ;
Pillay, D ;
Harrigan, PR ;
Camacho, R ;
Schapiro, JM ;
Shafer, RW .
PLOS MEDICINE, 2005, 2 (04) :325-337
[7]   HIV-1 subtype C reverse transcriptase and protease genotypes in Zimbabwean patients failing antiretroviral therapy [J].
Kantor, R ;
Zijenah, LS ;
Shafer, RW ;
Mutetwa, S ;
Johnston, E ;
Lloyd, R ;
Von Lieven, A ;
Israelski, D ;
Katzenstein, DA .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2002, 18 (18) :1407-1413
[8]   Comparison of capillary electrophoresis sequencing with the new CEQ 2000 DNA Analysis System to conventional gel based systems for HIV drug resistance analysis [J].
Merel, P ;
Pellegrin, I ;
Garrigue, I ;
Caumont, A ;
Schrive, MH ;
Birac, V ;
Bonot, P ;
Fleury, H .
JOURNAL OF VIROLOGICAL METHODS, 2001, 98 (01) :9-16
[9]   Comparison of drug resistance mutations and their interpretation in patients infected with non-B HIV-1 variants and matched patients infected with HIV-1 subtype B [J].
Montes, B ;
Vergne, L ;
Peeters, M ;
Reynes, J ;
Delaporte, E ;
Segondy, M .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2004, 35 (04) :329-336
[10]   HIV-1 resistance genotyping on dried serum spots [J].
Plantier, JC ;
Dachraoui, R ;
Lemée, V ;
Gueudin, M ;
Borsa-Lebas, F ;
Caron, F ;
Simon, F .
AIDS, 2005, 19 (04) :391-397
12