Beneficial Effect of Combination Therapy Comprising Angiotensin II Receptor Blocker Plus Calcium Channel Blocker on Plasma Adiponectin Levels

被引：5
|
作者：
Inoue, Yukiko [1 ]
Kakuma, Tatsuyuki [2 ]
Nonaka, Yoshisuke [2 ]
Sumi, Shunichiro [1 ]
Okamura, Keisuke [1 ]
Kodama, Sunao [1 ]
Ando, Chie [1 ]
Niimura, Hideya [1 ]
Miyoshi, Kei [1 ]
Tsuchiya, Yoshihiro [1 ]
Yamanouchi, Yoshio [1 ]
Urata, Hidenori [1 ]
机构：
[1] Fukuoka Univ, Chikushi Hosp, Dept Cardiovasc Dis, Chikushino, Fukuoka 8188502, Japan
[2] Kurume Univ, Ctr Biostat, Fukuoka, Japan
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2010年 / 32卷 / 01期
关键词：
ADIPOCYTE-DERIVED PROTEIN; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE; ESSENTIAL-HYPERTENSION; JAPANESE POPULATION; RANDOMIZED-TRIAL; BLOOD-PRESSURE; RISK; TELMISARTAN; AMLODIPINE;
D O I：
10.3109/10641960902960516
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The study aim was to examine the effect of combination therapy comprising angiotensin receptor blocker plus calcium antagonist on post-treatment plasma adiponectin levels compared to pretreatment levels. There was a significant gender difference in the relationship between preadiponectin level and age. In the search for contributing factors for treatment-based changes in adiponectin levels, these effects of gender and age were considered in statistical analysis. The adiponectin level in the combination therapy group was further increased compared to that in each of the monotherapy groups, despite there being no significant difference in antihypertensive effect, indicating that the combined medication provided an effect beyond that of lowering blood pressure.</.
引用
收藏
页码：21 / 28
页数：8
相关论文
共 50 条
  • [21] Combination of Angiotensin II Receptor Antagonist with Calcium Channel Blocker or Diuretic as Antihypertensive Therapy for Patients with Chronic Kidney Disease
    Ishimitsu, Toshihiko
    Ohno, Eri
    Nakano, Nobuyuki
    Furukata, Satoshi
    Akashiba, Akira
    Minami, Junichi
    Numabe, Atsushi
    Matsuoka, Hiroaki
    CLINICAL AND EXPERIMENTAL HYPERTENSION, 2011, 33 (06) : 366 - 372
  • [22] The beyond effects of antihypertensive drug on diabetes, using calcium channel blocker and angiotensin II receptor blocker
    Uno, Y.
    Morita, H.
    Ikeda, T.
    Mori, I.
    Fujioka, K.
    Okada, H.
    Fujikake, T.
    Miyauchi, R.
    Kajita, K.
    Ishizuka, T.
    DIABETOLOGIA, 2009, 52 : S467 - S468
  • [23] Calcium channel blocker versus angiotensin II receptor blocker in autosomal dominant polycystic kidney disease
    Nutahara, K
    Higashihara, E
    Horie, S
    Kamura, K
    Tsuchiya, K
    Mochizuki, T
    Hosoya, T
    Nakayama, T
    Yamamoto, N
    Higaki, Y
    Shimizu, T
    NEPHRON CLINICAL PRACTICE, 2005, 99 (01): : C18 - C23
  • [24] Kombinationstherapie mit AT1-Antagonist plus Kalziumantagonist bei nierenkranken PatientenCombination therapy with angiotensin II receptor blocker plus calcium channel blocker for patients with kidney disease
    S. Frerk
    U. Wenzel
    Der Nephrologe, 2013, 8 (2): : 167 - 168
  • [25] Combination of direct rennin inhibitor - aliskiren, angiotensin II receptor blocker - valsartan, and calcium channel blocker - amlodipine, in therapy of hypertensive patient with gout (case report)
    Dralova, O. V.
    Maksimov, M. L.
    RATIONAL PHARMACOTHERAPY IN CARDIOLOGY, 2011, 7 (04) : 468 - 472
  • [26] Angiotensin receptor blocker (ARB)-diuretic versus ARB-calcium channel blocker combination therapy for hypertension uncontrolled by ARB monotherapy
    Oshikawa, Jin
    Toya, Yoshiyuki
    Morita, Satoshi
    Taguri, Masataka
    Hanaoka, Kazushige
    Hasegawa, Toshio
    Kaizu, Kazo
    Kamata, Kouju
    Kobayashi, Shuzo
    Ohtake, Takayasu
    Sato, Takeo
    Yasuda, Gen
    Kimura, Kenjiro
    Umemura, Satoshi
    CLINICAL AND EXPERIMENTAL HYPERTENSION, 2014, 36 (04) : 244 - 250
  • [27] Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levels
    Komine, N
    Khang, S
    Wead, LM
    Blantz, RC
    Gabbai, FB
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (01) : 159 - 164
  • [28] Albuminuria-reducing effect of angiotensin II receptor blocker plus hydrochlorothiazide combination therapy in renal transplant recipients
    Naganuma, Toshihide
    Takemoto, Yoshiaki
    Uchida, Junji
    Ootoshi, Taiyou
    Kuwabara, Nobuyuki
    Maeda, Satoshi
    Nakatani, Tatsuya
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2012, 4 (01) : 105 - 108
  • [29] Angiotensin II for Treatment of Calcium Channel Blocker Overdose
    Felzer, J. R.
    Hoskote, S. S.
    Chalmers, S.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207
  • [30] ANGIOTENSIN II RECEPTOR BLOCKER IS PREFERABLE TO CALCIUM CHANNEL BLOCKER TO IMPROVE NOCTURNAL DIPPING PATTERN IN UNTREATED HYPERTENSIVES
    Cho, Jin-Man
    Hwang, Hui-Jeong
    Jin, Eun-Sun
    Park, Chang-Bum
    Sohn, Il-Suk
    Kim, Chong-Jin
    JOURNAL OF CLINICAL HYPERTENSION, 2013, 15 (07): : 519 - 519
12345