Beneficial Effect of Combination Therapy Comprising Angiotensin II Receptor Blocker Plus Calcium Channel Blocker on Plasma Adiponectin Levels

被引：5
|
作者：
Inoue, Yukiko [1 ]
Kakuma, Tatsuyuki [2 ]
Nonaka, Yoshisuke [2 ]
Sumi, Shunichiro [1 ]
Okamura, Keisuke [1 ]
Kodama, Sunao [1 ]
Ando, Chie [1 ]
Niimura, Hideya [1 ]
Miyoshi, Kei [1 ]
Tsuchiya, Yoshihiro [1 ]
Yamanouchi, Yoshio [1 ]
Urata, Hidenori [1 ]
机构：
[1] Fukuoka Univ, Chikushi Hosp, Dept Cardiovasc Dis, Chikushino, Fukuoka 8188502, Japan
[2] Kurume Univ, Ctr Biostat, Fukuoka, Japan
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2010年 / 32卷 / 01期
关键词：
ADIPOCYTE-DERIVED PROTEIN; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE; ESSENTIAL-HYPERTENSION; JAPANESE POPULATION; RANDOMIZED-TRIAL; BLOOD-PRESSURE; RISK; TELMISARTAN; AMLODIPINE;
D O I：
10.3109/10641960902960516
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The study aim was to examine the effect of combination therapy comprising angiotensin receptor blocker plus calcium antagonist on post-treatment plasma adiponectin levels compared to pretreatment levels. There was a significant gender difference in the relationship between preadiponectin level and age. In the search for contributing factors for treatment-based changes in adiponectin levels, these effects of gender and age were considered in statistical analysis. The adiponectin level in the combination therapy group was further increased compared to that in each of the monotherapy groups, despite there being no significant difference in antihypertensive effect, indicating that the combined medication provided an effect beyond that of lowering blood pressure.</.
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收藏
页码：21 / 28
页数：8
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