FeCl3-Promoted One-Step Synthesis of Spiro[4.5]decane Derivatives

被引：4

作者：

Zheng, Deping ^{[1
]}

Ma, Zuodong ^{[1
]}

Gong, Wanchun ^{[1
]}

Xie, Zhixiang ^{[1
]}

Li, Ying ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

SYNLETT | 2010年 / 14期

基金：

中国国家自然科学基金;

关键词：

spiro[4.5]decane; FeCl3; Prins cyclization; alpha-hydroxy alkynyl acetals; diastereoselectivity; PRINS-PINACOL SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; SILICA-GEL; CYCLIZATION; RING; CHLORIDE; ANNULATIONS; REAGENT; ACETALS; ETHER;

D O I：

10.1055/s-0030-1258541

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A FeCl3-promoted synthesis of spiro[4.5]decane derivatives has been developed from 2-(5,5-dimethoxypentyl)-1-substituted cyclopentanols with high diastereoselectivity. These interesting compounds are formed through a cascade process involving a FeCl3-promoted dehydration of alcohol followed by FeCl3-mediated Prins cyclization.

引用

收藏

页码：2169 / 2173

页数：5

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