Mutatis mutandis: Are we diagnosing too many people with non-celiac gluten sensitivity? Multiple case report

被引：6

作者：

Borghini, Raffaele ^{[1
]}

Donato, Giuseppe ^{[2
]}

Di Tola, Marco ^{[1
]}

Isonne, Claudia ^{[1
]}

Picarelli, Antonio ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Internal Med & Med Specialties, Policlin Umberto 1, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dept Clin Med, Policlin Umberto 1, I-00185 Rome, Italy

来源：

TURKISH JOURNAL OF GASTROENTEROLOGY | 2014年 / 25卷 / 03期

关键词：

Case finding; celiac disease; celiac serology; celiac testing; non-celiac gluten sensitivity; organ culture; ORGAN-CULTURE; DISEASE; TESTS;

D O I：

10.5152/tjg.2014.6221

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report three patients presenting with gluten-related signs and symptoms. Since villous height/crypt depth ratio, intraepithelial lymphocyte count, and serum antibody tests were not diagnostic for celiac disease (CD), a diagnosis of non-celiac gluten sensitivity (NCGS) was suggested. On the other hand, antibodies suggestive for CD surprisingly showed positive results in the duodenal biopsy organ culture of all three cases. The reported cases suggest the precious potential role that organ culture systems may play in differentiating CD from NCGS. This method should be recommended when gluten-related disorders are suspected in order to reduce the inappropriate diagnosis of NCGS.

引用

页码：319 / 322

页数：4

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