Wilson's disease with myoclonus and white matter lesions

被引：15

作者：

Barbosa, Egberto Reis

Silveira-Moriyama, Laura

Machado, Alexandre Costa

Bacheschi, Luiz Alberto

Rosemberg, Sergio

Scaff, Milberto

机构：

[1] Univ Sao Paulo, Sch Med, Dept Neurol, BR-01234001 Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Sch Med, Dept Pathol, BR-01234001 Sao Paulo, SP, Brazil

来源：

PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷 / 03期

关键词：

myoclonus; white matter lesions; Wilson disease;

D O I：

10.1016/j.parkreldis.2006.03.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

White matter lesions (WML) and epilepsy have been occasionally seen in Wilson's disease. No cases of generalized myoclonus have been reported so far. We present a patient with psychiatric symptoms starting at age 16, followed by tremor, generalized dystonia and severe generalized myoclonus. In addition to classical findings, the MRI showed also extensive WML in temporal, parietal and frontal regions, preserving interhemispheric fibers. Necropsy revealed marked alterations of white matter, cortex and basal ganglia. We subsequently review the literature concerning WML and myoclonus in Wilson's disease. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：185 / 188

页数：4

共 10 条

[1] CLINICAL, CT AND EVOKED-POTENTIAL MANIFESTATIONS IN WILSONS-DISEASE WITH CEREBRAL WHITE MATTER INVOLVEMENT [J].