A benzothizole-based fluorescent probe for Hg2+ recognition utilizing ESIPT coupled AIE characteristics

被引：71

作者：

Xu, Dong ^{[1
]}

Tang, Lijun ^{[1
]}

Tian, Mingyu ^{[1
]}

He, Ping ^{[1
]}

Yan, Xiaomei ^{[2
]}

机构：

[1] Bohai Univ, Coll Chem & Chem Engn, Jinzhou 121013, Peoples R China

[2] Dalian Med Univ, Coll Lab Med, Dalian 116044, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 37期

基金：

中国国家自然科学基金;

关键词：

Hg2+ recognition; Dithioacetal; ESIPT; AIE; Fluorescent probe; Cell imaging; LIVING CELLS; CHEMODOSIMETER; WATER; MERCURY(II); IONS; BENZOTHIAZOLE; CHEMOSENSOR; EMISSION; HG(II); AGGREGATION;

D O I：

10.1016/j.tetlet.2017.08.016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new benzothizole-based fluorescent probe 1 for Hg2+ recognition utilizing "ESIPT+AIE" strategy has been developed. In THE/H2O (1:1, v/v, PBS 20 mM, pH = 8.5) mixed solution, probe 1 displays rapid fluorescence responses to Hg2+ ions with high selectivity and sensitivity through Hg2+-triggered releasing of a compound possessing "ESIPT+AIE" characteristics. Cell imaging investigations indicate that probe I is cell permeable with low toxicity to MCF-7 cells, and applicable to detect Hg2+ ions in living MCF-7 cells. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：3654 / 3657

页数：4

共 41 条

[1] Inhibition of the human thioredoxin system - A molecular mechanism of mercury toxicity [J].

Carvalho, Cristina M. L. ;

Chew, Eng-Hui ;

Hashemy, Seyed Isaac ;

Lu, Jun ;

Holmgren, Arne .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (18) :11913-11923

[2] FLUOROMETRIC CHEMODOSIMETRY - MERCURY(II) AND SILVER(I) INDICATION IN WATER VIA ENHANCED FLUORESCENCE SIGNALING [J].

CHAE, MY ;

CZARNIK, AW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (24) :9704-9705

[3] Selective Hg2+ signaling via dithiane to aldehyde conversion of an ESIPT fluorophore [J].

Chang, In Jung ;

Hwang, Keum Saem ;

Chang, Suk-Kyu .

DYES AND PIGMENTS, 2017, 137 :69-74

[4] Synthesis, Structure, and Hg2+-Ion-Sensing Properties of Stable Calixazasmaragdyrins [J].

Chatterjee, Tamal ;

Areti, Sivaiah ;

Ravikanth, Mangalampalli .

INORGANIC CHEMISTRY, 2015, 54 (06) :2885-2892

[5] Fluorescent and colorimetric sensors for environmental mercury detection [J].

Chen, Guiqiu ;

Guo, Zhi ;

Zeng, Guangming ;

Tang, Lin .

ANALYST, 2015, 140 (16) :5400-5443

[6] A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics [J].

Chen, Liyan ;

Wu, Di ;

Lim, Chang Su ;

Kim, Dayoung ;

Nam, Sang-Jip ;

Lee, Woolin ;

Kim, Gyungmi ;

Kim, Hwan Myung ;

Yoon, Juyoung .

CHEMICAL COMMUNICATIONS, 2017, 53 (35) :4791-4794

[7] Highly sensitive and selective ESIPT-based fluorescent probes for detection of Pd2+ with large Stocks shifts [J].

Chen, Tiantian ;

Wei, Tingwen ;

Zhang, Zhijie ;

Chen, Yahui ;

Qiang, Jian ;

Wang, Fang ;

Chen, Xiaoqiang .

DYES AND PIGMENTS, 2017, 140 :392-398

[8] Naphthylthiourea-modified permethylcyclodextrin as a highly sensitive and selective "turn-on" fluorescent chemosensor for Hg2+ in water and living cells [J].

Chen, Yong ;

Sun, Zhan-Hu ;

Song, Bao-E ;

Liu, Yu .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (15) :5530-5534

[9] New fluoro- and chromogenic chemosensors for the dual-channel detection of Hg2+ and F- [J].

Ding, Li ;

Wu, Minjing ;

Li, Yiru ;

Chen, Yi ;

Su, Jianhua .

TETRAHEDRON LETTERS, 2014, 55 (34) :4711-4715

[10] Novel "turn-on'' fluorescent chemodosimeters based on thioxanthen-9-thione for the selective detection of mercuric ions in aqueous media [J].

Ding, Li ;

Zou, Qi ;

Qu, Yi ;

Su, Jianhua .

RSC ADVANCES, 2012, 2 (11) :4754-4758

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