RENEB/EURADOS field exercise 2019: robust dose estimation under outdoor conditions based on the dicentric chromosome assay

被引：22

作者：

Endesfelder, David ^{[1
]}

Oestreicher, Ursula ^{[1
]}

Kulka, Ulrike ^{[1
]}

Ainsbury, Elizabeth A. ^{[2
]}

Moquet, Jayne ^{[2
]}

Barnard, Stephen ^{[2
]}

Gregoire, Eric ^{[3
]}

Martinez, Juan S. ^{[3
]}

Trompier, Francois ^{[3
]}

Ristic, Yoann ^{[3
]}

Woda, Clemens ^{[4
]}

Waldner, Lovisa ^{[5
]}

Beinke, Christina ^{[6
]}

Vral, Anne ^{[7
]}

Barquinero, Joan-Francesc ^{[8
]}

Hernandez, Alfredo ^{[8
]}

Sommer, Sylwester ^{[9
]}

Lumniczky, Katalin ^{[10
]}

Hargitai, Rita ^{[10
]}

Montoro, Alegria ^{[11
]}

Milic, Mirta ^{[12
]}

Monteiro Gil, Octavia ^{[13
]}

Valente, Marco ^{[14
]}

Bobyk, Laure ^{[14
]}

Sevriukova, Olga ^{[15
]}

Sabatier, Laure ^{[16
,17
]}

Prieto, Maria Jesus ^{[18
]}

Moreno Domene, Mercedes ^{[18
]}

Testa, Antonella ^{[19
]}

Patrono, Clarice ^{[19
]}

Terzoudi, Georgia ^{[20
]}

Triantopoulou, Sotiria ^{[20
]}

Histova, Rositsa ^{[21
]}

Wojcik, Andrzej ^{[22
,23
]}

机构：

[1] BfS, Bundesamt Strahlenschutz, Ingolstaedter Landstr 1, D-85764 Oberschleissheim, Germany

[2] CRCE, Publ Hlth England, Didcot, Oxon, England

[3] Inst Radioprotect & Surete Nucl, Fontenay Aux Roses, France

[4] Helmholtz Zentrum Munchen, Inst Radiat Med, Neuherberg, Germany

[5] Lund Univ, Med Radiat Phys, Dept Translat Med, Malmo, Sweden

[6] Bundeswehr Inst Radiobiol, Munich, Germany

[7] Univ Ghent, Fac Med & Hlth Sci, Ghent, Belgium

[8] Univ Autonoma Barcelona, Dept Anim Biol Plant Biol & Ecol, Bellaterra, Spain

[9] Inst Chem & Tech Jadrowej, Warsaw, Poland

[10] Natl Publ Hlth Ctr, Unit Radiat Med, Dept Radiobiol & Radiohyg, Budapest, Hungary

[11] Univ Politecn Fe, Serv Protecc Radiol Hosp, Lab Dosimetria Biol, Valencia, Spain

[12] Inst Med Res & Occupat Hlth, Mutagenesis Unit, Zagreb, Croatia

[13] Univ Lisbon, Inst Super Tecn, Ctr Ciencias & Tecnol Nucl, Lisbon, Portugal

[14] Armed Forces Biomed Res Inst, Dept Radiat Biol, Bretigny Sur Orge, France

[15] Radiat Protect Ctr, Dept Expertise & Exposure Monitoring, Vilnius, Lithuania

[16] PROCyTOX, Commissariat Energie Atom & Energies Alternat, Fontenay Aux Roses, France

[17] Univ Paris Saclay, Grad Sch Life Sci & Hlth, Paris, France

[18] Hosp Gen Univ Gregorio Maranon, Lab Dosimetria Biol, Madrid, Spain

[19] Agenzia Nazl Nuove Tecnol Energia & Sviluppo Econ, Rome, Italy

[20] Natl Ctr Sci Res Demokritos, Hlth Phys Radiobiol & Cytogenet Lab, Athens, Greece

[21] Natl Ctr Radiobiol & Radiat Protect, Dept Radiobiol, Sofia, Bulgaria

[22] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden

[23] Jan Kochanowski Univ Humanities & Sci, Inst Biol, Kielce, Poland

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2021年 / 97卷 / 09期

关键词：

Dicentric chromosome; RENEB; EURADOS; inter-laboratory comparison; biological dosimetry; RETROSPECTIVE DOSIMETRY METHODS; TOOTH ENAMEL DOSIMETRY; PART; INTERCOMPARISON EXERCISE; BIOLOGICAL DOSIMETRY; SEMIPALATINSK REGION; EUROPEAN NETWORK; EPR DOSIMETRY; RENEB; RADIATION;

D O I：

10.1080/09553002.2021.1941380

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Purpose Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life exposure scenarios. Materials and methods For the dicentric chromosome assay (DCA), blood tubes were located at anthropomorphic phantoms positioned in different geometries and were irradiated with a 1.36 TBq Ir-192-source. For each exposure condition, dose estimates were provided by at least one laboratory and for four conditions by 17 participating RENEB laboratories. Three radio-photoluminescence glass dosimeters were placed at each tube to assess reference doses. Results The DCA results were homogeneous between participants and matched well with the reference doses (>= 95% of estimates within +/- 0.5 Gy of the reference). For samples close to the source systematic underestimation could be corrected by accounting for exposure time. Heterogeneity within and between tubes was detected for reference doses as well as for DCA doses estimates. Conclusions The participants were able to successfully estimate the doses and to provide important information on the exposure scenarios under conditions closely resembling a real-life situation.

引用

页码：1181 / 1198

页数：18

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