Recent Findings in Molecular Basis of Inflammation and Anti-inflammatory Plants

被引:48
作者
Kazemi, Sedigheh [1 ]
Shirzad, Hedayatollah [1 ]
Rafieian-Kopaei, Mahmoud [2 ]
机构
[1] Shahrekord Univ Med Sci, Basic Hlth Sci Inst, Cellular & Mol Res Ctr, Shahrekord, Iran
[2] Shahrekord Univ Med Sci, Basic Hlth Sci Inst, Med Plants Res Ctr, Shahrekord, Iran
关键词
Inflammation; immune system; inflammatory mechanisms; inflammatory mediators; medicinal plants; injuries; EXPERIMENTAL ANIMAL-MODELS; INNATE IMMUNE ACTIVATION; TOLL-LIKE-RECEPTORS; AQUEOUS EXTRACT; ANTINOCICEPTIVE ACTIVITIES; METHANOL EXTRACT; VITEX-NEGUNDO; ESSENTIAL OIL; ANTIPYRETIC ACTIVITIES; ANTIOXIDANT ACTIVITY;
D O I
10.2174/1381612824666180403122003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Inflammation is one of the most important body responses provided by the immune system since it ensures survival when tissues are affected by injuries or infections. The inflammatory response is an important process for maintenance of normal tissue homeostasis. In contrast to acute inflammation, chronic inflammation does not have a useful impact. Prevention and suppression of inflammation are necessary to reduce patient suffering and to preserve the integrity of multiple organs. Unfortunately, commercial available anti-inflammatory drugs are not free from side effects. Hence, there is an urgent need for introducing potent, nontoxic or less toxic antiinflammatory drugs. Recently, substantial progress has been made in the understanding of inflammatory mechanisms which may open new avenues for the preparation of novel anti-inflammatory drugs. Medicinal plants are also promising sources for preparation of such novel drugs. Taking into consideration the anti-inflammatory activities of a large group of medicinal plants, this article, in addition to describing recent advances in progress in understanding the molecular basis of inflammation, presents the most important medicinal plants with antiinflammatory activity.
引用
收藏
页码:1551 / 1562
页数:12
相关论文
共 134 条
  • [1] Evaluation of pharmacological activity of Hibiscus tiliaceus
    Abdul-Awal, S. M.
    Nazmir, Sonia
    Nasrin, Sonia
    Nurunnabi, Tauhidur Rahman
    Uddin, Shaikh Jamal
    [J]. SPRINGERPLUS, 2016, 5
  • [2] Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides
    Abreu, P
    Matthew, S
    González, T
    Costa, D
    Segundo, MA
    Fernandes, E
    [J]. LIFE SCIENCES, 2006, 78 (14) : 1578 - 1585
  • [3] Afolayan AJ, 2010, AFR J BIOTECHNOL, V9, P1225
  • [4] Afsar U.AHMED, 2011, [Frontiers in Biology, 生物学前沿], V6, P274
  • [5] Agarwal S.S., 1988, INDIAN J PHARM, V20, P86
  • [6] Akinsulire OR, 2007, AFR J TRADIT COMPLEM, V4, P338
  • [7] Pathogen recognition and innate immunity
    Akira, S
    Uematsu, S
    Takeuchi, O
    [J]. CELL, 2006, 124 (04) : 783 - 801
  • [8] Al-Howiriny T.A., 2003, J NATURAL REMEDIES, V3, P54
  • [9] In vitro pharmacological investigations of Sapindus trifoliatus in various migraine targets
    Arulmozhi, DK
    Sridhar, N
    Bodhankar, SL
    Veeranjaneyulu, A
    Arora, SK
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2004, 95 (2-3) : 239 - 245
  • [10] Analgesic and anti-inflammatory activity of Argyreia speciosa root
    Bachhav, R. S.
    Gulecha, V. S.
    Upasani, C. D.
    [J]. INDIAN JOURNAL OF PHARMACOLOGY, 2009, 41 (04) : 158 - 161