Oxidative stress and aging: Learning from yeast lessons

被引：43

作者：

Eleutherio, Elis ^{[1
]}

Brasil, Aline de Araujo ^{[1
]}

Franca, Mauro Braga ^{[1
]}

Gomes de Almeida, Diego Seixas ^{[1
]}

Rona, Germana Breves ^{[1
]}

Silva Magalhaes, Rayne Stfhany ^{[1
]}

机构：

[1] Fed Univ Rio de Janeiro UFRJ, Inst Chem, BR-21941909 Rio De Janeiro, Brazil

来源：

FUNGAL BIOLOGY | 2018年 / 122卷 / 06期

关键词：

Cancer; Lifespan; Neurodegenerative diseases; Reactive oxygen species (ROS); Saccharomyces cerevisiae; SACCHAROMYCES-CEREVISIAE HOMOLOG; DNA TOPOISOMERASE-II; P53; TUMOR-SUPPRESSOR; HUMAN PROTEIN-TAU; ALPHA-SYNUCLEIN; SUPEROXIDE-DISMUTASE; GENOMIC INSTABILITY; PARKINSONS-DISEASE; MUTANT HUNTINGTIN; NEURODEGENERATIVE DISEASES;

D O I：

10.1016/j.funbio.2017.12.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The yeast Saccharomyces cerevisiae has played a vital role in the understanding of the molecular basis of aging and the relationship of aging process with oxidative stress (non-homeostatic accumulation of Reactive Oxygen Species, ROS). The mammalian and yeast antioxidant responses are similar and over 25 % of human-degenerative disease related genes have close homologues in yeast. The reduced genetic redundancy of yeast facilitates visualization of the effect of a deleted or mutated gene. By manipulating growth conditions, yeast cells can survive only fermenting (low ROS levels) or respiring (increased ROS levels), which facilitates the elucidation of the mechanisms involved with acquisition of tolerance to oxidative stress. Furthermore, the yeast databases are the most complete of all eukaryotic models. In this work, we highlight the value of S. cerevisiae as a model to investigate the oxidative stress response and its potential impact on aging and age-related diseases. (C) 2017 British Mycological Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：514 / 525

页数：12

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