Effects of neuronal drebrin on actin dynamics

被引：9

作者：

Grintsevich, Elena E. ^{[1
,2
]}

机构：

[1] Calif State Univ Long Beach, Dept Chem & Biochem, Long Beach CSULB, Long Beach, CA 90840 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles UCLA, Los Angeles, CA 90095 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2021年 / 49卷 / 02期

关键词：

BINDING PROTEIN DREBRIN; BUNDLING ACTIVITY; EXCITATORY SYNAPSES; FORMIN; STABILIZATION; PLASTICITY; FILAMENTS; CLONING;

D O I：

10.1042/BST20200577

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drebrin is a key regulator of actin cytoskeleton in neuronal cells which is critical for synaptic plasticity, neuritogenesis, and neuronal migration. It is also known to orchestrate a cross-talk between actin and microtubules. Decreased level of drebrin is a hallmark of multiple neurodegenerative disorders such as Alzheimer's disease. Despite its established importance in health and disease, we still have a lot to learn about drebrin's interactome and its effects on cytoskeletal dynamics. This review aims to summarize the recently reported novel effects of drebrin on actin and its regulators. Here I will also reflect on the most recent progress made in understanding of the role of drebrin isoforms and posttranslational modifications on its functionality.

引用

页码：685 / 692

页数：8

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