Gender differences in liver disease and the drug-dose gender gap

被引：65
作者：
Buzzetti, Elena [1 ]
Parikh, Pathik M. [1 ]
Gerussi, Alessio [1 ,2 ]
Tsochatzis, Emmanuel [1 ]
机构：
[1] Royal Free Hosp, UCL Inst Liver & Digest Hlth, London, England
[2] Univ Udine, Dept Expt & Clin Med Sci, Internal Med Unit, Udine, Italy
来源：
PHARMACOLOGICAL RESEARCH | 2017年 / 120卷
关键词：
Gender; Liver toxicity; Liver disease; Systematic review; HEPATITIS-B-VIRUS; PRIMARY BILIARY-CIRRHOSIS; HEPATOCELLULAR-CARCINOMA DEVELOPMENT; AUTOIMMUNE HEPATITIS; ORAL-CONTRACEPTIVES; SERUM TESTOSTERONE; NATURAL-HISTORY; FEMALE SEX; HEREDITARY HEMOCHROMATOSIS; SPONTANEOUS CLEARANCE;
D O I：
10.1016/j.phrs.2017.03.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Although gender-based medicine is a relatively recent concept, it is now emerging as an important field of research, supported by the finding that many diseases manifest differently in men and women and therefore, might require a different treatment. Sex-related differences regarding the epidemiology, progression and treatment strategies of certain liver diseases have long been known, but most of the epidemiological and clinical trials still report results only about one sex, with consequent different rate of response and adverse reactions to treatment between men and women in clinical practice. This review reports the data found in the literature concerning the gender -related differences for the most representative hepatic diseases. (C) 2017 Elsevier Ltd. All rights reserved.
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收藏
页码：97 / 108
页数：12
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