Bivalent polyether ionophores: Synthesis and biological evaluation of C2-symmetric salinomycin dimers

被引：12

作者：

Antoszczak, Michal ^{[1
]}

Maj, Ewa ^{[2
]}

Borgstrom, Bjorn ^{[3
]}

Oredsson, Stina ^{[4
]}

Huczynski, Adam ^{[1
]}

Wietrzyk, Joanna ^{[2
]}

Strand, Daniel ^{[3
]}

机构：

[1] Adam Mickiewicz Univ, Dept Bioorgan Chem, Fac Chem, Umultowska 89b, PL-61614 Poznan, Poland

[2] Polish Acad Sci, Ludwik Hirszfeld Inst Immunol & Expt Therapy, Rudolfa Weigla 12, PL-53114 Wroclaw, Poland

[3] Lund Univ, Dept Chem, Ctr Anal & Synth, Box 124, S-22100 Lund, Sweden

[4] Lund Univ, Dept Biol, S-22100 Lund, Sweden

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 24期

基金：

瑞典研究理事会;

关键词：

Ionophore antibiotics; Multivalent structures; Glaser-type coupling reaction; Anti-proliferative activity; SRB assay; STEM-CELL SELECTIVITY; ANTIPROLIFERATIVE ACTIVITY; BREAST-CANCER; ANTIBACTERIAL ACTIVITY; CYTOTOXICITY; DERIVATIVES; X-537A; ANTIBIOTICS; ANALOGS; COMPLEX;

D O I：

10.1016/j.tetlet.2017.05.023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient methods for the synthesis of C-2 -symmetric dimers of salinomycin joined at either the Cl or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low mu M range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2396 / 2399

页数：4

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