Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Ce(SO4)2-SiO2 as a Heterogeneous and Recyclable Catalyst

被引：9

作者：

Pei, Wen ^{[1
]}

Wang, Qin ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn & Mat, Hangzhou 310014, Zhejiang, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 08期

关键词：

Biginelli; Ce(SO4)2-SiO2; 3; 4-dihydropyrimidinones; solvent-free; ONE-POT SYNTHESIS; BIGINELLI REACTION; IMPROVED PROTOCOL; DIHYDROPYRIMIDINONES;

D O I：

10.1080/00397910903061076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient synthesis of 3,4-dihydropyrimidinones or thiones is described, using silica-supported ceric sulfate [Ce(SO4)2-SiO2] as a heterogeneous catalyst from an aldehyde, 1,3-dicarbonyl compound, and urea or thiourea at 110 degrees C under solvent-free conditions. Compared with the classical Biginelli reaction, this new method consistently has better yields, short reaction time, easy separation, and tolerance toward various functional groups.

引用

页码：1209 / 1215

页数：7

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