Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study

被引：56

作者：

Andersson, Charlotte ^{[1
,2
]}

Enserro, Danielle ^{[3
]}

Sullivan, Lisa ^{[3
]}

Wang, Thomas J. ^{[1
,2
,4
]}

Januzzi, James L., Jr. ^{[5
]}

Benjamin, Emelia J. ^{[1
,2
,6
,7
,8
]}

Vita, Joseph A. ^{[9
,10
]}

Hamburg, Naomi M. ^{[9
,10
]}

Larson, Martin G. ^{[1
,2
]}

Mitchell, Gary F. ^{[11
]}

Vasan, Ramachandran S. ^{[1
,2
,6
,7
,8
]}

机构：

[1] Boston Univ, Framingham Heart Study, Framingham, MA USA

[2] NHLBI, Framingham Heart Study, Framingham, MA USA

[3] Boston Univ, Dept Biostat, Framingham, MA USA

[4] Vanderbilt Univ, Div Cardiovasc Med, 221 Kirkland Hall, Nashville, TN 37235 USA

[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA

[6] Boston Univ, Sch Med, Sect Prevent Med, Boston, MA 02118 USA

[7] Boston Univ, Sch Med, Cardiol Sect, Boston, MA 02118 USA

[8] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[9] Boston Univ, Sch Med, Evans Dept Med, Boston, MA 02118 USA

[10] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

[11] Cardiovasc Engn Inc, Norwood, MA USA

来源：

ATHEROSCLEROSIS | 2016年 / 248卷

关键词：

Vascular stiffness; Endothelial function; Biomarkers; ST2; GDF-15; Troponin I; General population; GROWTH-DIFFERENTIATION FACTOR-15; FLOW-MEDIATED DILATION; ARTERIAL STIFFNESS; SYSTOLIC HYPERTENSION; AORTIC STIFFNESS; SENSITIVE ASSAY; PULSE PRESSURE; ASSOCIATION; MORTALITY; ATHEROSCLEROSIS;

D O I：

10.1016/j.atherosclerosis.2016.02.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: Growth differentiation factor-15 (GDF-15), soluble (s) ST2, and high-sensitivity troponin-I (hs-TnI) are associated with incident cardiovascular disease (CVD) including heart failure, yet the underlying mechanisms are not fully understood. We investigated if GDF-15, sST2, and hs-TnI are related to subclinical vascular dysfunction in the community, which may explain the relations of these biomarkers with CVD. Methods: We evaluated 1823 Framingham Study participants (mean age 61 +/- 10 years, 54% women) who underwent routine assessment of vascular function. We related circulating GDF-15, sST2, and hs-TnI concentrations to measures of arterial stiffness (carotid-femoral pulse wave velocity, CFPWV; augmentation index; and forward pressure wave amplitude, FW), endothelial-dependent vasodilation (flow-mediated dilation, FMD), and baseline and hyperemic brachial flow velocities using linear regression adjusting for standard risk factors. Results: After multivariable adjustment, GDF-15 levels were positively associated with CFPWV (0.044 [95% confidence interval 0.007-0.081] standard deviation [SD] change per SD increase in log(e)[GDF-15], p = 0.02) and FW (0.076 [0.026-0.126] SD change per SD increase in log(e)[GDF-15], p = 0.003) and inversely related to FMD (-0.051 [-0.101-0.0003] SD change per SD increase in log(e)[GDF-15], p = 0.048). sST2 was positively associated with CFPWV (0.032 [0.0005-0.063] SD change per SD increase in log(e)[sST2], p = 0.046), and hs-TnI inversely associated with hyperemic flow velocity (-0.041 [-0.082 -0.0004] SD change per SD increase in log(e)[hs-TnI], p = 0.048). Conclusion: In our community-based investigation, individual cardiac stress biomarkers were differentially related to select aspects of vascular function. These findings may contribute to the associations of circulating GDF-15, sST2, and hs-TnI with incident CVD and heart failure. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：245 / 251

页数：7

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