Advances in Traumatic Brain Injury Biomarkers

被引:15
作者
Nishimura, Kengo [1 ]
Cordeiro, Joacir G. [1 ]
Ahmed, Aminul I. [2 ]
Yokobori, Shoji [3 ]
Gajavelli, Shyam [4 ]
机构
[1] Univ Miami, Neurol Surg, Miami, FL 33136 USA
[2] Kings Coll London, Wolfson Ctr Age Related Dis, London, England
[3] Nippon Med Sch, Div Neurosurg Emergency, Dept Emergency & Crit Care Med, Tokyo, Japan
[4] Lacerta Therapeut, Neurosci, Alachua, FL USA
关键词
brain trauma indicator; uchl-1; gfap; neurologic prognosis; serum biomarkers; traumatic brain injury; prognostic biomarkers; ACUTE SUBDURAL-HEMATOMA; COMPUTED-TOMOGRAPHY; UNITED-STATES; HEAD-INJURY; MODERATE; HEMORRHAGE; IMPACT; DAMAGE; TIME;
D O I
10.7759/cureus.23804
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Traumatic brain injury (TBI) is increasingly a major cause of disability across the globe. The current methods of diagnosis are inadequate at classifying patients and prognosis. TBI is a diagnostic and therapeutic challenge. There is no Food and Drug Administration (FDA)-approved treatment for TBI yet. It took about 16 years of preclinical research to develop accurate and objective diagnostic measures for TBI. Two brain-specific protein biomarkers, namely, ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein, have been extensively characterized. Recently, the two biomarkers were approved by the FDA as the first blood-based biomarker, Brain Trauma Indicator (TM) (BTI (TM)), via the Breakthrough Devices Program. This scoping review presents (i) TBI diagnosis challenges, (ii) the process behind the FDA approval of biomarkers, and (iii) known unknowns in TBI biomarker biology. The current lag in TBI incidence and hospitalization can be reduced if digital biomarkers such as hard fall detection are standardized and used as a mechanism to alert paramedics to an unresponsive trauma patient.
引用
收藏
页数:9
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