The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis

被引：106

作者：

McCann, SJ ^{[1
]}

Pond, SM ^{[1
]}

James, KM ^{[1
]}

Le Couteur, DG ^{[1
]}

机构：

[1] Univ Queensland, Princess Alexandra Hosp, Dept Med, Brisbane, Qld 4102, Australia

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1997年 / 153卷 / 01期

基金：

英国医学研究理事会;

关键词：

Parkinson's disease; cytochrome P450 2D6; genetics; polymorphism; debrisoquine hydroxylase; meta-analysis;

D O I：

10.1016/S0022-510X(97)00179-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We performed a case-control study to investigate the association of the poor metaboliser genotype of the cytochrome P450 2D6 gene with Parkinson's disease (PD). Genotyping was determined by the polymerase chain reaction followed by digestion with restriction enzymes. The poor metaboliser genotype was more frequent in 112 patients with PD than in 206 matched controls (odds ratio 1.7, 95% CI: 0.94-2.45), A meta-analysis of these results together with ten other published studies gave a pooled odds ratio for the poor metaboliser genotype of 1.47 (95% CI: 1.18-1.96, P=0.01). Thus, the poor metaboliser genotype has a small but highly significant association with PD which would be easily missed in small studies. Research now should focus on the mechanism of this association. (C) 1997 Elsevier Science B.V.

引用

页码：50 / 53

页数：4

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