Eudesmane and aromadendrane sesquiterpenoids from the Vietnamese soft coral Sinularia erecta

被引：10

作者：

Nguyen Thi Huong ^{[1
]}

Ninh Thi Ngoc ^{[1
]}

Nguyen Van Thanh ^{[1
]}

Nguyen Hai Dang ^{[1
]}

Nguyen Xuan Cuong ^{[1
,2
]}

Nguyen Hoai Nam ^{[1
]}

Do Cong Thung ^{[3
]}

Ho Van The ^{[4
]}

Vo Sy Tuan ^{[4
]}

Phan Van Kiem ^{[1
]}

Chau Van Minh ^{[1
]}

机构：

[1] VAST, Inst Marine Biochem, Hanoi, Vietnam

[2] Grad Univ Sci & Technol, VAST, Hanoi, Vietnam

[3] VAST, Inst Marine Environm & Resources, Haiphong, Vietnam

[4] VAST, Inst Oceanog, Nhatrang, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 15期

关键词：

Sinularia erecta; sesquiterpenoid; eudesmane; aromadendrane; cytotoxicity; GORGONIAN MENELLA-WOODIN; GUAIANE SESQUITERPENOIDS; TERPENOIDS; CONSTITUENTS; METABOLITES;

D O I：

10.1080/14786419.2017.1402326

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Using various chromatographic separations, eight sesquiterpenoids (1-8), including one new compound 3 beta,5 alpha-dihydroxyeudesma-4(15),11-diene (1), were isolated from the MeOH extract of the Vietnamese soft coral Sinularia erecta. The structure elucidation was confirmed by spectroscopic experiments including 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities against three human cancer cell lines (A-549, HeLa and PANC-1) of all isolated compounds were evaluated by MTT-based colorimetric assays. Compound 1 exhibited selective cytotoxicity against the A549 cell line with IC50 of 14.79 +/- 0.91 mu M. [GRAPHICS] .

引用

页码：1798 / 1802

页数：5

共 22 条

[1] TERPENOID AND STEROID CONSTITUENTS OF THE INDIAN-OCEAN SOFT CORAL SINULARIA-MAXIMA [J].