Anticancer Agents from Diverse Natural Sources

被引：4
作者：
Khazir, Jabeena [1 ]
Riley, Darren L. [1 ]
Pilcher, Lynne A. [1 ]
De-Maayer, Pieter [2 ,3 ]
Mir, Bilal Ahmad [2 ,3 ]
机构：
[1] Univ Pretoria, Dept Chem, ZA-0028 Pretoria, South Africa
[2] Univ Pretoria, Dept Genet, Ctr Microbial Ecol & Genom, ZA-0028 Pretoria, South Africa
[3] Univ Pretoria, Genom Res Inst, ZA-0028 Pretoria, South Africa
来源：
NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
Cancer; Drugs; Endophytes; Marine Organisms; Natural products; Plant derived anticancer drugs; CRYPTOPHYCIN ANALOG LY355703; CELL LUNG-CANCER; PHASE-II TRIAL; METASTATIC BREAST-CANCER; SAGOPILONE ZK-EPO; EVERY; WEEKS; SABARUBICIN-MEN-10755; INTRAVENOUS-INFUSION; KINASE INHIBITOR; MARINE PRODUCTS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This review attempts to portray the discovery and development of anticancer agents/drugs from diverse natural sources. Natural molecules from these natural sources including plants, microbes and marine organisms have been the basis of treatment of human diseases since the ancient times. Compounds derived from nature have been important sources of new drugs and also serve as templates for synthetic modification. Many successful anti-cancer drugs currently in use are naturally derived or their analogues and many more are under clinical trials. This review aims to highlight the invaluable role that natural products have played, and continue to play, in the discovery of anticancer agents.
引用
收藏
页码：1655 / 1669
页数：15
相关论文
共 196 条
  • [1] Antioxidant and Anti-Protease Activities of Diazepinomicin from the Sponge-Associated Micromonospora Strain RV115
    Abdelmohsen, Usama Ramadan
    Szesny, Matthias
    Othman, Eman Maher
    Schirmeister, Tanja
    Grond, Stephanie
    Stopper, Helga
    Hentschel, Ute
    [J]. MARINE DRUGS, 2012, 10 (10): : 2208 - 2221
  • [2] Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance
    Abraham, Ioana
    El Sayed, Khalid
    Chen, Zhe-Sheng
    Guo, Huiqin
    [J]. MARINE DRUGS, 2012, 10 (10) : 2312 - 2321
  • [3] Synergistic effect of histone deacetylase inhibitors FK228 and m-carboxycinnamic acid bis-hydroxamide with proteasome inhibitors PSI and PS-341 against gastrointestinal adenocarcinoma cells
    Adachi, M
    Zhang, YB
    Zhao, XD
    Minami, T
    Kawamura, R
    Hinoda, Y
    Imai, K
    [J]. CLINICAL CANCER RESEARCH, 2004, 10 (11) : 3853 - 3862
  • [4] A phase II clinical and pharmacokinetic study of intravenous exatecan mesylate (DX-8951f) in patients with untreated metastatic gastric cancer
    Ajani, JA
    Takimoto, C
    Becerra, CR
    Silva, A
    Baez, L
    Cohn, A
    Major, P
    Kamida, M
    Feit, K
    De Jager, R
    [J]. INVESTIGATIONAL NEW DRUGS, 2005, 23 (05) : 479 - 484
  • [5] Amna T, 2012, BRAZ J MICROBIOL, V43, P1476, DOI 10.1590/S1517-838220120004000032
  • [6] Pharmacokinetic and pharmacodynamic study of IST-622, a novel synthetic derivative of chartreusin, by oral administration in a phase II study of patients with breast cancer
    Asai, G
    Yamamoto, N
    Toi, M
    Shin, E
    Nishiyama, K
    Sekine, T
    Nomura, Y
    Takashima, S
    Kimura, M
    Tominaga, T
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2002, 49 (06) : 468 - 472
  • [7] Phase II Study of Plitidepsin 3-Hour Infusion Every 2 Weeks in Patients With Unresectable Advanced Medullary Thyroid Carcinoma
    Baudin, Eric
    Droz, Jean P.
    Paz-Ares, Luis
    van Oosterom, Allan T.
    Cullell-Young, Martin
    Schlumberger, Martin
    [J]. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2010, 33 (01): : 83 - 88
  • [8] Phase II study of first-line sagopilone plus prednisone in patients with castration-resistant prostate cancer: a phase II study of the Department of Defense Prostate Cancer Clinical Trials Consortium
    Beer, T. M.
    Smith, D. C.
    Hussain, A.
    Alonso, M.
    Wang, J.
    Giurescu, M.
    Roth, K.
    Wang, Y.
    [J]. BRITISH JOURNAL OF CANCER, 2012, 107 (05) : 808 - 813
  • [9] Bellarosa D, 2005, ANTICANCER RES, V25, P2119
  • [10] CONTRIBUTIONS TO THE STUDY OF MARINE PRODUCTS .32. THE NUCLEOSIDES OF SPONGES .1.
    BERGMANN, W
    FEENEY, RJ
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1951, 16 (06) : 981 - 987
12345678910