Characterization of mammalian selenoproteomes

被引：1817
作者：
Kryukov, GV
Castellano, S
Novoselov, SV
Lobanov, AV
Zehtab, O
Guigó, R
Gladyshev, VN [1 ]
机构：
[1] Univ Nebraska, Dept Biochem, Lincoln, NE 68588 USA
[2] Univ Pompeu Fabra, Ctr Regulacio Genom, Inst Municipal Invest Med, Grp Recerca Informat Biomed, Barcelona 08003, Catalonia, Spain
来源：
SCIENCE | 2003年 / 300卷 / 5624期
关键词：
D O I：
10.1126/science.1083516
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.
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页码：1439 / 1443
页数：6
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