Maternal factors in the origin of isolated anorectal malformations - a population-based case-control study

被引：8

作者：

Vermes, Gabor ^{[1
]}

Laszlo, Daniel ^{[2
]}

Matrai, Akos ^{[3
]}

Czeizel, Andrew E. ^{[4
]}

Acs, Nandor ^{[3
]}

机构：

[1] Mil Hosp, State Hlth Ctr, Dept Obstet & Gynecol, Budapest, Hungary

[2] St Stephens Hosp, Dept Obstet & Gynecol, Budapest, Hungary

[3] Semmelweis Univ, Sch Med, Dept Obstet & Gynecol 2, Budapest, Hungary

[4] Fdn Community Control Hereditary Dis, Budapest, Hungary

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2016年 / 29卷 / 14期

基金：

匈牙利科学研究基金会;

关键词：

Acute and chronic maternal disease; anorectal malformation; drug treatment; population-based case-control study; RISK-FACTORS; CONGENITAL-ABNORMALITIES; EARLY-PREGNANCY; SEVERE NAUSEA; ASSOCIATION; DEFECTS;

D O I：

10.3109/14767058.2015.1085014

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: In most patients affected by isolated anorectal malformation (IARM), the etiology is unknown. Thus, the aim of this study was to analyze the possible role of maternal risk factors in the origin of IARM. Methods: The study samples included 231 cases with IARM, 361 matched and 38 151 population controls without any defect in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. Cases with IARM were evaluated in the function of maternal diseases and related drug use. Results: The findings of this case-control study suggested that cases with IARM have an obvious male excess. The mothers of cases with IARM had a lower incidence of severe nausea and vomiting in pregnancy and a higher incidence of acute infectious diseases in the urinary tract. Conclusions: Lack of nausea and vomiting in pregnancy and the higher incidence of urinary tract infections may have a role in the development of IARM.

引用

页码：2316 / 2321

页数：6

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