A dual role of Erk signaling in embryonic stem cells

被引：29
作者：
Ma, Xinwei
Chen, Haixia
Chen, Lingyi [1 ]
机构：
[1] Nankai Univ, Coll Life Sci, 94 Weijin Rd, Tianjin 300071, Peoples R China
来源：
EXPERIMENTAL HEMATOLOGY | 2016年 / 44卷 / 03期
基金：
中国国家自然科学基金;
关键词：
MOUSE ES CELLS; SELF-RENEWAL; REGULATORY CIRCUITRY; NEGATIVE FEEDBACK; GROUND-STATE; PLURIPOTENCY; PHOSPHORYLATION; EPIBLAST; DIFFERENTIATION; SPECIFICITY;
D O I：
10.1016/j.exphem.2015.12.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Erk signaling plays a critical role in maintaining the pluripotency of mouse embryonic stem cells (ESCs). Inhibition of Mek/Erk signaling by pharmacologic Mek inhibitor promotes self renewal and pluripotency of mouse ESCs. However, knockout of Erkl/2 genes compromises the self-renewal and genomic stability of mouse ESCs. In this review, we summarize recent progress in understanding the role of Erk signaling in pluripotency maintenance, discuss the dual role of Erk in mouse ESCs, and provide explanations for the conflicting data regarding Mek inhibition and Erk knockout. Remaining questions and the prospects of Erk signaling in pluripotency maintenance are also discussed. Copyright (C) 2016 ISEH- International Society for Experimental Hematology. Published by Elsevier Inc.
引用
收藏
页码：151 / 156
页数：6
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