Sex differences on the behavior and oxidative stress after ketamine treatment in adult rats subjected to early life stress

被引：9

作者：

Abelaira, Helena M. ^{[1
]}

Veron, Deise Cristina ^{[1
]}

de Moura, Airam B. ^{[1
]}

Carlessi, Anelise S. ^{[1
]}

Borba, Laura A. ^{[1
]}

Botelho, Maria Eduarda M. ^{[1
]}

Andrade, Natalia M. ^{[1
]}

Martinello, Nicolly S. ^{[1
]}

Zabot, Gabriel C. ^{[2
]}

Joaquim, Larissa ^{[3
]}

Biehl, Erica ^{[3
]}

Bonfante, Sandra ^{[3
]}

Budni, Josiane ^{[2
]}

Petronilho, Fabricia ^{[3
]}

Quevedo, Joao ^{[1
,4
,5
,6
]}

Reus, Gislaine Z. ^{[1
]}

机构：

[1] Univ Southern Santa Catarina UNESC, Translat Psychiat Lab, Grad Program Hlth Sci, Criciuma, SC, Brazil

[2] Univ Southern Santa Catarina, Hlth Sci Unit, Expt Neurol Lab, Grad Program Hlth Sci, Criciuma, SC, Brazil

[3] Univ Southern Santa Catarina UNISUL, Lab Clin & Expt Pathophysiol, Postgrad Program Hlth Sci, Tubarao, SC, Brazil

[4] Univ Texas Hlth Sci Ctr Houston UTHlth, Ctr Excellence Mood Disorders, McGovern Med Sch, Faillace Dept Psychiat & Behav Sci, Houston, TX USA

[5] Univ Texas MD Anderson Canc Ctr UTHlth, Grad Sch Biomed Sci, Neurosci Grad Program, Houston, TX USA

[6] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Faillace Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA

来源：

BRAIN RESEARCH BULLETIN | 2021年 / 172卷

关键词：

Oxidative stress; interleukin-6; Ketamine; Inflammation; Maternal deprivation; Major depressive disorder; FORCED SWIM TEST; NEUROTROPHIC FACTOR; NADPH OXIDASES; ANIMAL-MODEL; DEPRESSION; BRAIN; GENDER; MYELOPEROXIDASE; INFLAMMATION; HIPPOCAMPUS;

D O I：

10.1016/j.brainresbull.2021.04.021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study aimed to evaluate the effects of ketamine, on behavioral parameters, oxidative stress, and inflammation in the brain of male and female rats submitted to the animal model of maternal deprivation (MD). Wistar rats were deprived of maternal care in the first 10 days of life (three hours daily). As adults, male and female rats were divided: control + saline deprived + saline and deprived + ketamine (15 mg/kg). The behavior was evaluated through the open field and forced swimming tests. Then brain was removed for analysis of oxidative damage, the activity of superoxide dismutase (SOD), catalase (CAT), and myeloperoxidase (MPO) activity, and levels of interleukin-6 (IL-6). MD induced depressive behavior in males and ketamine reversed these changes. MD induced an increase in lipid peroxidation in males and females; ketamine reversed these effects in males. Protein carbonylation was increased in males and females, with ketamine decreasing such effects. The concentration of nitrite/nitrate increased in males and females, whereas ketamine decreased this in the PFC of males. SOD and CAT activities were decreased in male and female deprived groups and deprived groups treated with ketamine. MPO activity and IL-6 levels increased in males subjected to MD and ketamine reversed this effect. The results suggest that stressful events in early life can induce behavioral, neuroimmune changes, and oxidative stress, however, such effects depend on sex and brain area. Ketamine presents anti-inflammatory and antioxidant properties and could be considered an alternative for individuals who are resistant to classical treatments.

引用

页码：129 / 138

页数：10

共 69 条

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