Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

被引：63

作者：

White, Nicholas J. ^{[1
,2
]}

Ashley, Elizabeth A. ^{[1
]}

Recht, Judith ^{[1
]}

Delves, Michael J. ^{[3
]}

Ruecker, Andrea ^{[3
]}

Smithuis, Frank M. ^{[2
,4
]}

Eziefula, Alice C. ^{[5
]}

Bousema, Teun ^{[5
]}

Drakeley, Chris ^{[5
]}

Chotivanich, Kesinee ^{[1
,7
]}

Imwong, Mallika ^{[1
,6
]}

Pukrittayakamee, Sasithon ^{[1
,7
]}

Prachumsri, Jetsumon ^{[8
]}

Chu, Cindy ^{[1
,9
]}

Andolina, Chiara ^{[1
,9
]}

Bancone, Germana ^{[1
]}

Hien, Tran T. ^{[10
]}

Mayxay, Mayfong ^{[11
]}

Taylor, Walter R. J. ^{[1
]}

von Seidlein, Lorenz ^{[1
]}

Price, Ric N. ^{[1
,12
,13
]}

Barnes, Karen I. ^{[14
]}

Djimde, Abdoulaye ^{[15
]}

ter Kuile, Feiko ^{[16
]}

Gosling, Roly ^{[17
]}

Chen, Ingrid ^{[17
]}

Dhorda, Mehul J. ^{[2
,18
]}

Stepniewska, Kasia ^{[18
]}

Guerin, Philippe ^{[18
]}

Woodrow, Charles J. ^{[1
,2
]}

Dondorp, Arjen M. ^{[1
,2
]}

Day, Nicholas P. J. ^{[1
]}

Nosten, Francois H. ^{[1
,2
,9
]}

机构：

[1] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand

[2] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London, England

[4] Myanmar Oxford Clin Res Unit, Yangon, Myanmar

[5] London Sch Hyg & Trop Med, London WC1, England

[6] Mahidol Univ, Fac Trop Med, Dept Mol Trop Med & Genet, Bangkok, Thailand

[7] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok, Thailand

[8] Mahidol Univ, Fac Trop Med, Mahidol Vivax Res Unit, Bangkok, Thailand

[9] Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mae Sot, Tak, Thailand

[10] Univ Oxford, Hosp Trop Dis, Climat Res Unit, Ho Chi Minh City, Vietnam

[11] Mahosot Hosp, Lao Oxford Mahosot Hosp Wellcome Trust, Trust Res Unit, Microbiol Lab, Viangchan, Laos

[12] Charles Darwin Univ, Darwin, NT, Australia

[13] Global & Trop Hlth Div, Menzies Sch Hlth Res, Darwin, NT, Australia

[14] Univ Cape Town, Dept Med, Div Clin Pharmacol, ZA-7925 Cape Town, South Africa

[15] Univ Sci Tech & Technol Bamako, Fac Med & Odonto Stomat, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Bamako, Mali

[16] Univ Liverpool Liverpool Sch Trop Med, Liverpool, Merseyside, England

[17] UCSF Global Hlth Sci, Global Hlth Grp, San Francisco, CA USA

[18] Churchill Hosp, World Wide Antimalarial Resistance Network, Oxford OX3 7LJ, England

来源：

MALARIA JOURNAL | 2014年 / 13卷

基金：

英国惠康基金;

关键词：

SULFADOXINE-PYRIMETHAMINE; SEX-RATIOS; PRIMAQUINE; TRANSMISSION; CARRIAGE; INFECTIVITY; CHLOROQUINE; CHILDREN; CLEARANCE; ARTESUNATE;

D O I：

10.1186/1475-2875-13-483

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.

引用

页数：13

共 64 条

[1]

[Anonymous], 2010, Guidelines for the treatment of Malaria, DOI DOI 10.1080/03630269.2023.2168201

[2]

[Anonymous], 2012, Updated WHO Policy Recommendation: Single Dose Primaquine as a Gametocytocide in Plasmodium Falciparum Malaria

[3] Primaquine: the risks and the benefits [J].

Ashley, Elizabeth A. ;

Recht, Judith ;

White, Nicholas J. .

MALARIA JOURNAL, 2014, 13

[4] Gametocytes: insights gained during a decade of molecular monitoring [J].

Babiker, Hamza A. ;

Schneider, Petra ;

Reece, Sarah E. .

TRENDS IN PARASITOLOGY, 2008, 24 (11) :525-530

[5] THE EFFECT OF SMALL DOSES OF PLASMOCHIN ON THE VIABILITY OF GAMETOCYTES OF MALARIA AS MEASURED BY MOSQUITO INFECTION EXPERIMENTS [J].

Barber, M. A. ;

Komp, W. H. W. ;

Newman, B. M. .

PUBLIC HEALTH REPORTS, 1929, 44 (24) :1409-1420

[6]

Barber MA, 1927, 16 MED DEP UN FRUIT, P60

[7] Increased gametocytemia after treatment: An early parasitological indicator of emerging sulfadoxine-pyrimethamine resistance in falciparum malaria [J].

Barnes, Karen I. ;

Little, Francesca ;

Mabuza, Aaron ;

Mngomezulu, Nicros ;

Govere, John ;

Durrheim, David ;

Roper, Cally ;

Watkins, Bill ;

White, Nicholas J. .

JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (11) :1605-1613

[8] Low infectivity of Plasmodium falciparum gametocytes to Anopheles gambiae following treatment with sulfadoxine-pyrimethamine in Mali [J].

Beavogui, Abdoul H. ;

Djimde, Abdoulaye A. ;

Gregson, Aric ;

Toure, Abdoulaye M. ;

Dao, Adama ;

Coulibaly, Boubacar ;

Ouologuem, Dinkorma ;

Fofana, Bakary ;

Sacko, Adama ;

Tekete, Mamadou ;

Kone, Aminatou ;

Niare, Oumou ;

Wele, Mamadou ;

Plowe, Christopher V. ;

Picot, Stephane ;

Doumbo, Ogobara K. .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2010, 40 (10) :1213-1220

[9] Mosquito Feeding Assays to Determine the Infectiousness of Naturally Infected Plasmodium falciparum Gametocyte Carriers [J].

Bousema, Teun ;

Dinglasan, Rhoel R. ;

Morlais, Isabelle ;

Gouagna, Louis C. ;

van Warmerdam, Travis ;

Awono-Ambene, Parfait H. ;

Bonnet, Sarah ;

Diallo, Mouctar ;

Coulibaly, Mamadou ;

Tchuinkam, Timoleon ;

Mulder, Bert ;

Targett, Geoff ;

Drakeley, Chris ;

Sutherland, Colin ;

Robert, Vincent ;

Doumbo, Ogobara ;

Toure, Yeya ;

Graves, Patricia M. ;

Roeffen, Will ;

Sauerwein, Robert ;

Birkett, Ashley ;

Locke, Emily ;

Morin, Merribeth ;

Wu, Yimin ;

Churcher, Thomas S. .

PLOS ONE, 2012, 7 (08)

[10] Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination [J].

Bousema, Teun ;

Drakeley, Chris .

CLINICAL MICROBIOLOGY REVIEWS, 2011, 24 (02) :377-+

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